The concept of Mouth Dissolving Drug Delivery System emerged from the desire to provide patient with conventional mean of taking their medication. Oxcarbazepine is an anticonvulsant drug, mainly used as an add-on or first line treatment in adults and children. Due to sudden onset of attack, it is necessary to formulate antiepileptics into such a delivery system, which provide immediate relief. Hence, the present investigation was undertaken with a view to develop mouthdissolving tablets of oxcarbazepine, which offers a new range of product having desired characteristics and intended benefits. In this study, the mouth dissolving tablets were prepared. A mouth dissolving tablet was prepared by using superdisintegrants viz; crospovidone, croscarmellose sodium and sodium starch glycolate All the batches are prepared by direct compression method. Effect of disintegrants concentration on the disintegration behavior was evaluated, and all the tablets were evaluated for hardness, friability, weight variation, water absorption ratio, dissolution, and assay. Among the all preparations F8 emerged as the best formulation and showed maximum dissolution rate.

No abstract

The objective of the present investigation is to formulate gastroretentive dosage form of Nizatidine, widely prescribed in gastric and duodenal ulcers. The short biological half-life (1 -2 hours), maximum absorption in initial part of small intestine, colonic metabolism of Nizatidine favors' development of gastro retentive floating dosage form. In the present study sodium bicarbonate is use as a gas generating agent. The tablets were formulated using direct compression technology by employing semi synthetic polymers like HPMC K15M, and Sodium alginate. The prepared tablets were evaluated for various physicochemical parameters such as flow properties, hardness, weight variation, friability, in vitro buoyancy (floating lag time, total floating time), swelling studies, drug content and in-vitro drug release. Out of all formulations the one prepared with combination of HPMC K15M and Sodium alginate was optimized based on desired sustained release time (12hrs) and acceptable floating properties.The development of controlled-release formulations continues to be a big success for the Pharmaceutical Industry. The success of any technology relies on the ease of its manufacturing process and its reproducibility of desirable biopharmaceutical properties.

No abstract

No abstract