Background: Hypertension is a major public health problem in developed and developing countries.  Objective: to determine the prevalence and association of hyperuricemia with diagnosed cases of essential hypertension. Material and Methods:  A hospital based cross sectional study was conducted at Department of General Medicine in a Medical College. Results: Out of the total 235 cases with hypertension, 83.8% were in stage I hypertension while 16.2% were in stage II hypertension. Prevalence of hyperuricemia was seen as 27.7% among cases with hypertension.  Prevalence of hyperuricemia was 23.4% in cases with stage I hypertension while it was 50% in cases with stage II hypertension (p<0.01). Mean Systolic (153.2 vs 149.8 mmHg) and diastolic (99.8 vs 96.9 mm Hg) blood pressure was significantly more in cases with hyperuricemia (p<0.01).  A significant correlation was observed between serum uric acid levels and systolic and diastolic blood pressure i.e. serum uric acid levels increases with increase in blood pressure (p<0.01). Conclusion: Prevalence of hyperuricemia was significantly higher in diagnosed subjects with essential hypertension, affecting every one out of four individual. Mean serum uric acid levels were significantly associated with increase in systolic and diastolic blood pressure.

Background: Diabetes is the commonest metabolic disorder affecting the people all over the world. Objective of the study was to identify the diastolic dysfunction in type 2 diabetes mellitus patient to recognize the early involvement of heart.Methods: This cross sectional study was conducted in tertiary care hospital cases of type II diabetes mellitus coming to our hospital and giving informed consent. Period of study was from September 2016 to February 2018. Consecutive type of non-probability sampling was used for the selection of study subjects. A total of 54 diagnosed patients of type II diabetes mellitus coming to our hospital and giving informed consent were included in the study.Results: Prevalence of diastolic dysfunction was observed to be 44.4% in patients of type 2 diabetes mellitus without cardiac manifestations. Prevalence of diastolic dysfunction was seen in 47.4% males in comparison to 42.9% females. Prevalence of diastolic dysfunction was 11.1%, 77.3% and 80% in cases with disease duration of 0-5 years, 6-10 years and more than 10 years respectively. Prevalence of diastolic dysfunction was more in cases with poor glycaemic control i.e. hemoglobin A1c (HbA1c) value >8% as compared to cases with good glycemic control.Conclusions: There was an association between the prevalence of diastolic dysfunction with the increasing age. We had higher percentage of patients with diastolic dysfunction as duration of diabetes increased. Diastolic dysfunction was seen in 55.2% patients receiving oral hypoglycaemic agents (OHAs) as compared to 23.5% patients who were on insulin and 50% patients who were on both insulin and OHAs.