A considerable number of gastric cancers derive from stomach mucosa where chronic atrophic gastritis is severe and extensive. Based on the fact that the serum pepsinogen levels provide a precise measure of the extent of chronic atrophic gastritis, we have devised a mass screening method involving serum pepsinogen measurement to identify subjects at high risk of gastric cancer. In 1991, we screened 4,647 workers (male: 4,113, female: 534, mean age: 49.0 years) at a Japanese company using this method. Out of 875 subjects (18.8%) with a serum pepsinogen I level of less than 50 μg/liter and a pepsinogen I/II ratio of less than 3.0, 676 subjects (14.5%) were selected for further investigation by endoscopy. This led to the detection of four subjects (0.086%) with gastric cancer (three in an early stage) and four subjects with adenoma. The cancer detection rate of this new screening method was comparable, and in some respects superior, to that of the traditional barium X‐ray screening. Since the incidence of test‐positive subjects was as low as 10% amongst subjects aged less than 40, this screening method appears to be especially useful for screening of younger generations. The new method is less expensive than the traditional barium X‐ray and subjects experience little discomfort. Further, many serum samples can be quickly measured simultaneously. The results of this study have indicated that serum pepsinogen screening provides a valuable method for detecting gastric cancers.

When an earthquake occurs, a certain amount of time elapses before destructive seismic energy hits nearby population centers. Though this time is measured on the order of seconds, depending on the proximity of the rupture to a given city or town, a new public safety program in Japan is taking advantage of the fact that seismic energy travels slower than electronic communication.In this program, the Japan Meteorological Agency (JMA) rapidly determines the hypocenter (earthquake epicenter and focal depth) and magnitude of the earthquake by using real-time data from stations near the hypocenter. The distribution of strong ground shaking is anticipated quickly, and then the information is delivered immediately to government officials, representatives from various industries, members of the news media, and individuals before strong ground shaking reaches them. For example, on receiving the warning, the control room of a railway company can send an emergency notice to all train drivers to stop their trains immediately, elevators in buildings can be triggered to stop at the nearest floor and open their doors automatically, and surgeons can temporarily suspend their surgical operations to avoid risk to patients on operating tables.This innovative new service, called Earthquake Early Warning (EEW), started nationwide in Japan and became fully operational in October 2007. This service is definitely different from earthquake prediction. Although it is currently impossible to be aware of earthquakes before their occurrence (earthquake prediction), EEW operates with the assumption that it is possible to warn people located at a certain distance from the hypocenter before strong ground shaking reaches them.Even though the interval between the delivery of EEWs and the time when strong shaking reaches people is relatively short (counted in seconds), EEWs can be a useful and powerful tool for mitigating an earthquake disaster by giving people enough time to take appropriate safety measures in advance of strong shaking. Determining Hypocentral Parameters and Anticipating Seismic IntensityEarthquakes occur when stressed rock moves through brittle rupture. Two types of seismic waves are radiated from the hypocenter: One is the P wave, which travels at about 7 kilometers per second, and the other is the S wave, which travels at about 4 kilometers per second.EEW technology not only takes advantage of the relatively slow velocity of the seismic waves as compared with instantaneous electronic communication, but it also uses the difference in arrival time between P and S waves. The S wave is slower than the P wave, but the amplitude of the S wave is usually 3-10 times larger than that of the P wave. This generally means that stronger shaking is observed along the S wave.The hypocenter and magnitude of an earthquake are determined as quickly as possible using only early parts of the P waves at a few stations close to the hypocenter. Using information about the hypocenter and magnitude, the arrival time of the S waves and seismic intensit...

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