Monitoring of fetal electrocardiogram (fECG) would provide useful information about fetal wellbeing as well as any abnormal development during pregnancy. Recent advances in flexible electronics and wearable technologies have enabled compact devices to acquire personal physiological signals in the home setting, including those of expectant mothers. However, the high noise level in the daily life renders long-entrenched challenges to extract fECG from the combined fetal/maternal ECG signal recorded in the abdominal area of the mother. Thus, an efficient fECG extraction scheme is a dire need. In this work, we intensively explored various extraction algorithms, including template subtraction (TS), independent component analysis (ICA), and extended Kalman filter (EKF) using the data from the PhysioNet 2013 Challenge. Furthermore, the modified data with Gaussian and motion noise added, mimicking a practical scenario, were utilized to examine the performance of algorithms. Finally, we combined different algorithms together, yielding promising results, with the best performance in the F1 score of 92.61% achieved by an algorithm combining ICA and TS. With the data modified by adding different types of noise, the combination of ICA–TS–ICA showed the highest F1 score of 85.4%. It should be noted that these combined approaches required higher computational complexity, including execution time and allocated memory compared with other methods. Owing to comprehensive examination through various evaluation metrics in different extraction algorithms, this study provides insights into the implementation and operation of state-of-the-art fetal and maternal monitoring systems in the era of mobile health.

Fetal electrocardiogram (fECG) assessment is essential throughout pregnancy to monitor the wellbeing and development of the fetus, and to possibly diagnose potential congenital heart defects. Due to the high noise incorporated in the abdominal ECG (aECG) signals, the extraction of fECG has been challenging. And it is even a lot more difficult for fECG extraction if only one channel of aECG is provided, i.e., in a compact patch device. In this paper, we propose a novel algorithm based on the Ensemble Kalman filter (EnKF) for non-invasive fECG extraction from a single-channel aECG signal. To assess the performance of the proposed algorithm, we used our own clinical data, obtained from a pilot study with 10 subjects each of 20 min recording, and data from the PhysioNet 2013 Challenge bank with labeled QRS complex annotations. The proposed methodology shows the average positive predictive value (PPV) of 97.59%, sensitivity (SE) of 96.91%, and F1-score of 97.25% from the PhysioNet 2013 Challenge bank. Our results also indicate that the proposed algorithm is reliable and effective, and it outperforms the recently proposed extended Kalman filter (EKF) based algorithm.

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Our objective is to design triple-band implantable antennas with wide bandwidths and appropriate sizes for biomedical applications. The targeted design frequencies are 400 MHz, 2.4 GHz, and the new Wi-Fi band of 5.7 GHz. Three triple-band antennas with bandwidth improvements are presented to insure all-time data connection. The proposed triple-band implantable antennas benefit from combining long-distance data transfer at lower frequency bands and a higher effective bandwidth, and high-speed communications at higher frequency bands, which will have flexibility for a variety of applications. A comprehensive explanation of the design procedure to achieve multiple-band implantable antennas is provided. Furthermore, miniaturization techniques are utilized to design antennas in compact sizes suitable for biomedical applications. In this paper, three-layer structures including skin, fat, and muscle are used for the designs, then antennas are placed in the chest, neck, head, and hand of different human voxels to compare antennas’ performance. Additionally, normal and overweight human effects on antenna performance were compared. Antennas have 2 to 6 dBi directivity for telemetry usage, and they are designed to satisfy the absorption limit for the human body to keep the Specific Absorption Rate (SAR) averaged over 1 g of tissue less than 1.6 W/kg and over 10 g of tissue less than 2 W/kg, according to IEEE standard. The antennas include fractal, meandered, and comb types with sizes of 1.4 mm × 10 mm × 10 mm, 3.04 mm × 10 mm × 17.25 mm, and 1.4 mm × 12 mm × 12 mm, respectively. The designed antenna showed an impedance bandwidth of 53 MHz to 120 MHz, 90 MHz to 320 MHz, and 300 MHz to 1200 MHz at the three bands. The meandered antenna was selected for validation of simulations, and its S parameters were measured in the equivalent liquid phantom of body tissues.

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