The study was designed with the objective to examine the perceived social support (PSS) as a moderator between parental perceived stress (PPS) and quality of life (QOL) among parents having children with special needs. A sample of 300 parents was selected through purposive sampling from special education schools and health care centres of Lalamusa, Kharian, Gujrat and Gujranwala, Pakistan. Parental Perceived Stress Scale (PPSS), MultiDimensional Scale of Perceived Social Support (MDSPSS) and quality of life was measured through the Urdu version of the Quality of Life Questionnaire (Parent Version of QOLA) were administered to collect the data. Findings illustrated that PPS, QOL and PSS had statistically significant relationships (p < .001) with each other. Further, PPS is a significant moderator between PPS and QOL among targeted parents. On the basis of findings, it is concluded that there is an intense need of providing awareness and social support to empower parents for coping with stresses.