Introduction:An epidermoid cyst is a benign cyst usually found on the skin. Bone cysts are very rare and if they appear in bone they usually appear in the distal phalanges of the fingers. Epidermoid cysts of the jaws are uncommon.Case presentation:We present a case, of a 41 year-old female patient admitted to our department because of pain and swelling in the parotid and masseteric region–left side. There was no trismus, pathological findings in skin, high body temperature level, infra-alveolar nerves anesthesia or lymphadenopathy present. The orthopantomography revealed a cystic lesion and a unilocular lesion that included mandibular ramus on the left side with 3 cm in diameter. Under total anesthesia, a cyst had been reached and was enucleated. Histopathologic findings showed that the pathologic lesion was an epidermoid cyst.Discussion:Epidermoid and dermoid cysts are rare, benign lesions found throughout the body. Only a few cases in literature describe an intraossesus epidermoid cyst.Conclusion:Our case is an epidermoid cyst with a rare location in the region of the mandibular ramus. It is not associated with any trauma in this region except medical history reveals there was an operative removal of a wisdom tooth 12 years ago in the same side. These cysts are interesting from the etiological point of view. They should be considered in the differential diagnosis of other radiolucent lesions of the jaws. Surgically they have a very good prognosis, and are non-aggressive lesions.

After lung cancer colorectal cancer (Cc) is ranked the second, as a cause of cancer-related death. Th e purpose of this study was to analyze the Cc cases in our material with respect to all prognostic values including histological type and grade, vascular invasion, perineural invasion, and tumor border features. Th ere were investigated  cases of resection specimen with colorectal cancer, which were fi xed in buff ered neutral formalin and embedded in paraffi n. Tissue sections ((μm thick) were cut and stained with H&E. Adenocarcinoma was the most frequent histological type found in , of cases, in , of males and , of females; squamous cell carcinoma in ,, in , of males and , of females; mucinous carcinoma in ,, in , of males and , of females; while adenosquamous carcinoma, undiff erentiated carcinoma and carcinoma in situ in , of cases each. Dukes' classifi cation was used in order to defi ne the depth of invasion. Dukes B was found in , of cases, whereas in , of cases Dukes C was found. As far as histological grading is concerned, Cc was mostly with moderate diff erentiation (,) with neither vascular nor perineural invasion. Resection margins were in all cases free of tumor. Our data indicate that the pathologic features of the resection specimen constitute the most powerful predictors of postoperative outcome in Cc. Dukes' stage and degree of diff erentiation provide independent prognostic information in Cc. However, diff erentiation should be assessed by the worst pattern.

Th yroid cancer accounts for approximately  of total cancer cases in developed countries. Th e aim of this study has been to analyze the histopathological variants of thyroid tumours with regard to gender and age. Despite their relative rarity in our material, they exhibit a wide range of morphological patterns and biological behaviour. During the period from -,  biopsy cases of thyroid tumours, which were fi xed in buffered neutral formalin and embedded in paraffi n, have been reviewed. Tissue sections (μm thick) were cut and stained with hematoxylin and eosin (H&E). Follicular adenomas have been found in ,  of cases, thyroid carcinomas in , , whereas thyroid secondary carcinomas have been found in ,  of cases. As far as histological variants of thyroid carcinomas are concerned, most frequently found were papillary carcinomas in , of cases; followed by follicular carcinomas in , of cases; follicular variants of papillary carcinomas in , of cases; medullary carcinomas in , of cases, while anaplastic and Hurthle cell carcinomas have been found in , of cases each. All histological variants of thyroid tumours occurred more frequently in women than in men. Papillary carcinoma has been found in  of female cases. Th yroid tumours in our material mainly occurred in the third, the fourth and the fi fth decade of life. Our data indicate that apart from the fact that papillary carcinomas, well diff erentiated, and characterised by relatively good prognosis, were most frequent variants, certain morphological variants of it were associated with poor prognosis.

IntroductionDiffuse large B-cell lymphoma is a diffuse proliferation of large neoplastic B lymphoid cells with a nuclear size equal to or exceeding the normal macrophage nuclei. We report a case of a clear cell variant of diffuse large B-cell lymphoma involving a lymph node in the neck, which was clinically suspected of being metastatic carcinoma.Case presentationA 39-year-old Caucasian ethnic Albanian man from Kosovo presented with a rapidly enlarging lymph node in his neck, but he also disclosed B symptoms and fatigue. A cytological aspirate of the lymph node revealed pleomorphic features. Our patient underwent a cervical lymph node biopsy (large excision). The mass was homogeneously fish-flesh, pale white tissue replacing almost the whole structure of the lymph node. The lymph node biopsy showed a partial alveolar growth pattern, which raised clinical suspicion that it was an epithelial neoplasm. With regard to morphological and phenotypic features, we discovered large nodules in diffuse areas, comprising large cells with slightly irregular nuclei and clear cytoplasm admixed with a few mononuclear cells. In these areas, there was high mitotic activity, and in some areas there were macrophages with tangible bodies. Staining for cytokeratins was negative. These areas had the following phenotypes: cluster designation marker 20 (CD20) positive, B-cell lymphoma (Bcl)-2-positive, Bcl-6-, CD5-, CD3-, CD21+ (in alveolar patterns), prostate-specific antigen-negative, human melanoma black marker 45-negative, melanoma marker-negative, cytokeratin-7-negative and multiple myeloma marker 1-positive in about 30% of cells, and exhibited a high proliferation index marker (Ki-67, 80%).ConclusionAccording to the immunohistochemical findings, we concluded that this patient has a clear cell variant of diffuse large B-cell lymphoma of activated cell type, post-germinal center cell origin. Our patient is undergoing R-CHOP chemotherapy treatment.

IntroductionNeuroendocrine carcinoma of the gallbladder is a rather uncommon disease. We report a case of a neuroendocrine tumor that was located in the wall of the gallbladder and that extended into the liver.Case presentationA 52-year-old Caucasian woman presented with right-sided abdominal pain, ascites and jaundice. An MRI scan revealed a tumor mass located in the gallbladder wall and involving the liver. A partial hepatectomy and cholecystectomy were performed. Histology revealed a neuroendocrine tumor, which showed scattered Grimelius positive cells and immuno-expressed epithelial and endocrine markers. Our patient is undergoing chemotherapy treatment.ConclusionGastroenteropancreatic neuroendocrine tumors need a multidisciplinary approach, involving immunohistochemistry and molecular-genetic techniques.