Introdution: Based on researches, increased levels of vascular endothelial growth factor and antioxidant parameters in areas of the brain that are more affected by Parkinson's disease have a potential therapeutic effect. Therefore, the purpose of this study was to compare the effect of 6 weeks continuous and interval aerobic exercises on vascular endothelial growth factor and superoxide dismutase enzyme; Parkinson's rats. Methods: In this experimental study, 24 male Wistar male rats (12 weeks) with an average weight of 250 to 350 grams were used. Subjects were treated with reserpine to Parkinson's, then divided into 6 groups. Aerobic exercises were performed for 6 weeks. After 48 hours of the last training session, the rats were killed, then the tissue of the hippocampus was separated from other parts of the brain, and vascular endothelial growth factor and superoxide dismutase enzyme were measured using specific kits. The results were analyzed using one way analysis of variance analysis and Bonferroni post hoc test. Results: The results of this study showed that 6 weeks of continuous and interval aerobic exercise increased vascular endothelial growth factor levels in Parkinson's rats (p = 0.01). There was no significant difference between the two groups of interval exercises compared to the continuous training group (p = 0.87). Also, these exercises did not significantly affect the superoxide dismutase enzymes (p = 0.47). Conclusion: Based on the findings of this study, it has been shown that 6 weeks of continuous and periodic aerobic exercise increases the vascular endothelial growth factor, but these exercises  have not significantly changed the superoxide dismutase enzyme. Introdution: Based on researches, increased levels of vascular endothelial growth factor and antioxidant parameters in areas of the brain that are more affected by Parkinson's disease have a potential therapeutic effect. Therefore, the purpose of this study was to compare the effect of 6 weeks continuous and interval aerobic exercises on vascular endothelial growth factor and superoxide dismutase enzyme; Parkinson's rats. Methods: In this experimental study, 24 male Wistar male rats (12 weeks) with an average weight of 250 to 350 grams were used. Subjects were treated with reserpine to Parkinson's, then divided into 6 groups. Aerobic exercises were performed for 6 weeks. After 48 hours of the last training session, the rats were killed, then the tissue of the hippocampus was separated from other parts of the brain, and vascular endothelial growth factor and superoxide dismutase enzyme were measured using specific kits. The results were analyzed using one way analysis of variance analysis and Bonferroni post hoc test. Results: The results of this study showed that 6 weeks of continuous and interval aerobic exercise increased vascular endothelial growth factor levels in Parkinson's rats (p = 0.01). There was no significant difference between the two groups of interval exercises compared to the continuous training group (p = 0.87). Also, these exercises did not significantly affect the superoxide dismutase enzymes (p = 0.47). Conclusion: Based on the findings of this study, it has been shown that 6 weeks of continuous and periodic aerobic exercise increases the vascular endothelial growth factor, but these exercises  have not significantly changed the superoxide dismutase enzyme.

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Introduction: Despite the beneficial roles of nitric oxide, its excessive synthesis causes neurodegenerative diseases. Therefore, the aim of the present study was to compare the nitric oxide changes in the hippocampal tissue and the pain sensation of male Parkinson's rats after 6 weeks of continuous and interval training. Methods: In this experimental study, 24 Wistar male rats were used. Rats were treated with Parkinson's using reserpine, and then divided into four groups (n=6). Aerobic exercise was performed for 6 weeks and 5 sessions per week. The duration of training increased from the first to the sixth week, it increased from 15 minutes on the first day to 40 minutes in the sixth week. The interval group performed the specified duration of the exercise twice in the first week, four times in the second to fourth weeks, and six times in the fifth to sixth weeks. At the end of 6 weeks, pain sensation was measured using formalin test and then rats were sacrificed. The tissue of the hippocampus was separated, and nitric oxide was measured using the ELISA method and special kits. The results were analyzed using one-way analysis of variance and LSD follow-up. Results:The results showed that Parkinson's disease increased nitric oxide levels (p ≤0.05). Continuous and interval aerobic exercise reduced nitric oxide (p ≤0.05). There was no significant difference between the two training groups (p ≤0.68). In addition, Parkinson's control group showed a significant increase in pain compared to the control group (p ≤0.01). Two types of exercise reduced pain (p ≤0.05), but there was no significant difference between the two groups (p≤0.23). Conclusion:According to the findings of this study, continuous and periodic aerobic exercise reduced nitric oxide levels and pain in the rats of the Parkinson's model.