Background The Healthy Cities project supports municipal policymakers in the struggle to safeguard the health of urban citizens around the world (and in other limited geographies such as islands). Although Healthy Cities has been implemented in thousands of settings, no synthesis of implementation experiences have been conducted. In this article, we develop a scoping review protocol that can be applied to collect evidence on process evaluations of Healthy Cities. Methods To develop a scoping review protocol that could identify experiences evaluating the Healthy Cities project, we followed the PRISMA guidelines for Scoping Reviews (PRISMA-ScR). We applied these guidelines in consultation with a research librarian to design a search of the peer-reviewed literature, specifically Ovid Medline, Ovid Embase, Web of Science Core Collection, and Scopus databases, and a grey literature search. Discussion In addition to the aim of collecting evidence on Healthy Cities process evaluation experiences, the broader goal is to spark discussions and inform future evaluations of Healthy Cities. This work can also inform other evaluations of initiatives seeking to raise socio-political change, such as those focused on enhancing intersectoral and multisectoral action.

Leukocyte inflammatory responses require integrin cell-adhesion molecule signaling through spleen tyrosine kinase (Syk), a non-receptor kinase that binds directly to integrin β-chain cytoplasmic domains. Here, we developed a high-throughput screen to identify small molecule inhibitors of the Syk-integrin cytoplasmic domain interactions. Screening small molecule compound libraries identified the β-lactam antibiotics cefsulodin and ceftazidime, which inhibited integrin β-subunit cytoplasmic domain binding to the tandem SH2 domains of Syk (IC50 range, 1.02–4.9 µM). Modeling suggested antagonist binding to Syk outside the pITAM binding site. Ceftazidime inhibited integrin signaling via Syk, including inhibition of adhesion-dependent upregulation of interleukin-1β and monocyte chemoattractant protein-1, but did not inhibit ITAM-dependent phosphorylation of Syk mediated by FcγRI signaling. Our results demonstrate a novel means to target Syk independent of its kinase and pITAM binding sites such that integrin signaling via this kinase is abrogated but ITAM-dependent signaling remains intact. As integrin signaling through Syk is essential for leukocyte activation, this may represent a novel approach to target inflammation.

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One of the main issues for intermediate-level nuclear waste (ILW) is atmospheric corrosion in stainless steel. The impact of microstructure on the pit shapes on three orientations of the duplex stainless steel DSS 2205 plate and the relative humidity impact on the atmospheric corrosion pits of DSS beneath MgCl2 drops is determined through the use of four characterization tools: X-ray diffraction (XRD), Energy dispersive X-ray (EDX) analyses, Scanning electron microscopy (SEM), and optical microscopy. The pits on the top surface (LT) appears layered like an attack and mostly hemispherical, while the long transverse (LS) and short transverse (ST) planes reveal elongated strings. The map scan of EDX indicates mixed oxide inclusions and MnS inclusion existing in the steel alloy and the XRD analyses present the existence of two-phase both austenite γ and ferrite α peaks. The pit shape and area were influenced by relative humidity (RH) change. At RH 35% the trend of pits in 1-week exposure revealed a larger area of pit mouth than in RH 45%. For the same exposure time and in both RHs, the area seemed to be greater at the droplet’s center than in the edge of the droplet.