Background: Childbearing is an important phenomenon in demographic changes. The current fertility rate does not have the necessary level for proper succession of generations in Iran. Therefore, the present study aimed to determine roles of predictors of childbearing willingness in the center of Iran due to the important of childbearing and its association with fertility.Methods: The present cross-sectional study was conducted on 400 married citizens referred to comprehensive health centers in central Iran and they were selected by convenience sampling. Data was collected using a researcher-made questionnaire, and analyzed by SPSS 20. Descriptive and analytical tests of ordinal regression and factor analysis were also performed; and the significance level was considered to be less than 0.05.Results: In the present study, the mean (standard deviation) of participants' marriage age was 21.11 years. Results of the present study indicated that there were relationships between variables, namely family strength motivation, economic self-efficacy, emotional and religious motivation, physical barriers and childbearing tendency (P < 0.05). The chance of childbearing willingness increased by 7% by enhancing family strength motivation scores, 20% by increasing economic self-efficacy, and 6% by increasing emotional and religious motivation, but decreased by reducing physical barriers.Conclusion: Strengthening family strength motivation, economic self-efficacy, religious-emotional motivation, and efforts to remove physical barriers were effective in increasing childbearing.