Multidrug antituberculosis regimen is associated with diverse clinical patterns of cutaneous adverse drug reactions (CADR), ranging from mild and moderate such as pruritus, maculopapular exanthems, lichenoid eruptions, fixed drug eruptions and urticaria to severe and even life threatening ones like acute generalized exanthematous pustulosis (AGEP), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). These adverse reactions to antituberculosis drugs are commonly observed adverse events. This is of particular importance for high HIV prevalence settings and developing countries where tuberculosis is common infection resulting in higher occurrence rate of these reactions. There is still significant heterogenity in definition and classification of CADR, as well as diversity in treatment modalities following adverse reactions and rechallenge management. The aim of this review is to discuss clinical presentation, occurrence of CADR caused by antituberculosis drugs, to identify risk factors for intolerance of the standard therapy as well as to draw attention to importance of multi-disciplinary approach, early detection, prompt diagnosis and in time management of antituberculosis drugs associated CADR. CADR can cause significant treatment interruption and alteration, resulting in increased risk of treatment failure, drug resistance, relapses and increased risk of complications including even lethal outcome. Finally, it can be concluded that it is of great importance to identify the best possible treatment and preventive regimens in order to enable continuity of the antituberculosis therapy to the full extent.

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The role of nutrition in the treatment of common dermatoses is often overlooked. Nevertheless, there is a large amount of evidence suggesting that diet may have an important role in the pathogenesis, as well as in determining the clinical course of common skin disorders; including acne, psoriasis, atopic dermatitis and allergic contact dermatitis. Consequently, diet could have significant preventive or therapeutic impact in these skin conditions. Psoriasis, atopic dermatitis and allergic contact dermatitis are chronic relapsing skin disorders characterised by remissions and flare-ups, requiring long-term maintenance therapy. Although acne occurs most commonly during adolescence, and rarely continues into adulthood, it has a large impact on patients' self-confidence and self-image. For each of these skin conditions, a variety of foods may lead to exacerbation of the disease and may have a significant role in increasing the risk of other comorbidities. The aim of this review is to present current knowledge on the relationship between high-fat and high glycemic index diet and acne and psoriasis. Additionally, possible role of nutritional supplementation in such will also be reviewed. And finally, the role of dietary restriction in patients with atopic dermatitis and low nickel diet, in those who are sensitive to nickel, will be discussed. Although future studies are necessary in order to evaluate the effect of diet in these skin disorders, identifying certain foods as a potential factor that could contribute to exacerbation of the disease or to development of further complications can provide important preventive measure.

Food allergy is an adverse immune-mediated pathological reaction directed toward proteins or glycoproteins in food. It affects the skin, gastrointestinal, respiratory and cardiovascular systems, resulting in a broad spectrum of diverse clinical presentations. Consequently, establishing a diagnosis can present a great challenge. The prevalence rate of food allergy is increasing, particularly in modern industrialized countries, and is becoming a significant public health problem. There is still no current treatment, and avoidance of suspected food allergens remains the most important treatment modality. However, in order to avoid unnecessary dietary restrictions, food hypersensitivity should be confirmed using allergy tests prior to introduction of elimination diet. In cases of validation of food allergy, avoiding suspected foods are recommended. Education of patients is the cornerstone of prevention and therapy; providing all relevant information on how to exclude specific foods from the patient's diet, as well as how to detect and manage allergic reactions, especially in severe cases like anaphylaxis. This review aims at presenting the clinical picture and diagnosis, as well as discussing current treatment and preventive strategies for different types of food allergies.

Psorijaza je kronična upalna bolest koja pogađa 1-2% odrasle opće populacije. Bolest nije ograničena samo na kožu, već je povezana s nizom komorbiditeta, koji značajno utječu na kvalitetu života i predstavljaju povišeni rizik od različitih medicinskih poremećaja. Posljednjih godina, brojne publikacije su pokazale povišenu učestalost srčanožilnih bolesti i metaboličkog sindroma u bolesnika s psorijazom. Iako etiopatogenetska povezanost između ovih stanja još uvijek nije razjašnjena, čini se da dijele zajedničke patofi ziološke puteve u vidu sličnih upalnih komponenti. S obzirom na povišenu prevalenciju kardiovaskularnih komorbiditeta u bolesnika, psorijazi bi trebalo pristupiti kao multisistemskoj bolesti. Stoga je potreban multidisciplinarni pristup u cilju najučinkovitijeg liječenja bolesnika sa psorijazom.Kardiološki lijekovi često su povezani s nastankom ili pogoršanjem psorijaze, među kojima su beta-blokatori najčešći uzročni lijekovi. Potrebno je prepoznati ovu povezanost, s obzirom na to da je to kožna nuspojava koja značajno utječe na kvalitetu života, predstavlja veliko psihološko opterećenje i stigmatizaciju za bolesnika te ima značajan utjecaj na daljnju terapijsku suradljivost.