This study focuses on synthesizing novel nanocomposites, zinc(II)tetrakis(4-phenyl)porphyrin/Cu nanoparticles (ZnTPP/Cu-NPs),with antibacterial activity, fabricated through a single-step green procedure. In this regard, the self-assembly of ZnTPP was carried out through an acid–base neutralization method to prepare ZnTPP nanoparticles. Then, the copper nanoparticles (Cu-NPs) were grown on ZnTPP nanoparticles through a visible-light irradiated photochemical procedure in the absence and presence of polyacrylic acid (PAA) as a modulator. The effect of PAA on the morphological properties of the prepared nanocomposites was evaluated. Eventually, the antibacterial activity of nanocomposites with different morphologies was investigated. In this way, the average zone of inhibition growth of diameter, minimum inhibitory concentration, and minimum bactericidal concentration values was determined. Besides, the cytotoxicity of the nanocomposites was evaluated by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay MCF-7and (HEK-293) cell lines. The specific features of the synthesized nanocomposites identified them as antibacterial compounds which have therapeutic effects on breast cancer.

Three different palladium(II) complexes with ligands containing nitrogenized aromatic rings were investigated theoretically as model to obtain the computational band gap energies. The results demonstrated promising possibility for designing palladium(II) complexes with photocatalytic properties at visible light irradiation. Deliberated products were synthesized via grafting on the silica-coated FeO magnetic nanoparticles (FeO@SiO). Formation of complexes on the surface of FeO@SiO, as insoluble and reusable photocatalysts, was proved by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), thermogravimetric (TGA), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM), transmission electron microscope (TEM), and scanning electron microscopy (SEM) analyses. The trend of the band gap energies of prepared structures was calculated via experimental and theoretical methods. The photocatalytic capability of these nanoparticles was investigated in degradation of 2,4-dichlorophenol by means of HPLC analysis. A tentative reaction mechanism for the formation of intermediates was proposed. Graphical abstract ᅟ.

In this research, the one-step synthesis of novel porphyrin-based nanocomposites was performed easily using a photochemical under visible light illumination strategy. As a result, the focus of this research is on synthesizing and using decorated ZnTPP (zinc(II)tetrakis(4-phenyl)porphyrin) nanoparticles with Ag, Ag/AgCl/Cu, and Au/Ag/AgCl nanostructures as antibacterial agents. Initially, ZnTPP NPs were synthesized as a result of the self-assembly of ZnTPP. In the next step, in a visible-light irradiation photochemically process, the self-assembled ZnTPP nanoparticles were used to make ZnTPP/Ag NCs, ZnTPP/Ag/AgCl/Cu NCs, and ZnTPP/Au/Ag/AgCl NCs. A study on the antibacterial activity of nanocomposites was carried out for Escherichia coli, and Staphylococcus aureus as pathogen microorganisms by the plate count method, well diffusion tests, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) values determination. Thereafter, the reactive oxygen species (ROS) were determined by the flow cytometry method. All the antibacterial tests and the flow cytometry ROS measurements were carried out under LED light and in dark. The (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was applied to investigate the cytotoxicity of the ZnTPP/Ag/AgCl/Cu NCs, against Human foreskin fibroblast (HFF-1) normal cells. Due to the specific properties such as admissible photosensitizing properties of porphyrin, mild reaction conditions, high antibacterial properties in the presence of LED light, crystal structure, and green synthesis, these nanocomposites were recognized as kinds of antibacterial materials that are activated in visible light, got the potential for use in a broad range of medical applications, photodynamic therapy, and water treatment.