Introduction: Bone marrow examination is an important diagnostic tool and the cornerstone of hematology. Cytopenia is a descriptive term referring to a reduction in any of the three blood cell lineage erythrocytes, leukocytes and platelets. This study aimed toAims And Objectives: determine the clinical and etiological prole in patients of cytopenias undergone bone marrow examination. it was aMaterial And Methods: prospective observational hospital based study conducted over a period of 18 months (July 2016 to January 2018) in the department of Pathology, Krishna Institute of Medical Science, Secunderabad. Complete history, physical examination, complete blood count, peripheral blood lm and bone marrow aspiration was done in 400 patients who presented with cytopenias. Out of 400 patients, 208 cases were male and 192 wereResults: females with Male: female ratio 1.08:1. Age ranging from 1 to 87 years with mean age of patient's was 43.5 years. Out of 400 patients of cytopenia 167 cases were neoplastic and 226 cases were non-neoplastic while 7 cases showed normal marrow ndings. Findings in these cases included megaloblastic anemia, acute leukemia, immune thrombocytopenic purpura, and plasma cell myeloma as the commonest cause of pancytopenia, bicytopeia, thrombocytopenia and anemia respectively. Bone marrow evaluation is an important and effective tool in diagnosing andConclusion: evaluating hematological disorders.

Background: Systemic lupus erythematosus (SLE) can present with hematologic manifestations alone or with features of systemic involvement. Diagnosis may be delayed or missed at presentation time, especially in those with hematologic abnormalities as the initial manifestation, with low index of clinical suspicion or inadequate follow-up. Aim And Objectives: To study the prevalence and the type of hematologic manifestations in SLE from pathologist's perspective. Setting And Design: Retrospective observational study. Material And Methods: Study was done in 63 SLE patients in a tertiary care hospital in Secunderabad for duration of one and half years, from January 2018 to June 2019. Hematological parameters of the same were retrieved. Results :It was observed that anemia was the most common hematologic nding with iron deciency anemia (IDA) being the commonest cause followed by hemolytic anemia. Leucopenia with predominant lymphopenia was the most common WBC abnormality and thrombocytopenia was seen in majority of the patients. Bi and pancytopenia was also observed. Raised erythrocyte sedimentation rate (ESR) was a common nding. Deranged coagulation prole was seen due to secondary anti-phospholipid antibody (APLA) syndrome, hemolysis and sepsis on anticoagulant. Bone marrow studies showed varied ndings including hypocellularity, dyspoiesis in the erythroid, myeloid and megakaryocytic series and abnormal localisation of immature precursors (ALIP) aggregates. Conclusion: This study was conducted to estimate the proportion of patients with hematological abnormalities as the manifestation of SLE and to study the nature of hematological problems, so that the empirical treatment can be started.

Hematological manifestations of rheumatoid arthritis (RA) are very common. Blood dyscrasias and other hematological abnormalities are sometimes the rst sign of rheumatic disease. In addition, novel anti-rheumatic biological agents may cause cytopenias. It is crucial that hematologists be aware of these presentations so that they are diagnosed and treated in a timely manner. A logical approach using easily available tests should allow straightforward decisions about diagnosis and therapy to be made, even in patients with some of the rarer hematological manifestations. An observational study was done in RA patients in a tertiary care hospital to study the prevalence and the type of hematologic manifestations from a pathologist's perspective. It was observed that anemia is the most common hematologic nding seen in RA, iron deciency being the commonest cause of anemia, however hemolytic anemia was not seen. Leucocytosis was more common with predominant neutrophilia. Elevated platelet count, bicytopenia and pancytopenia were observed in RA along with raised ESR. Coagulation parameters were however within normal range. Bone marrow ndings (where studied) included tuberculosis and plasma cell neoplasm. Summary: This study was conducted to estimate the proportion of patients with hematological abnormalities as the manifestation of RA and to study the nature of these various hematological problems, so that the empirical treatment can be started and also to inform the clinical rheumatologists about the common and rarer hematological manifestations of RA.

Introduction: Radial neck fractures make up approximately 5% of elbow fractures in children and patient is having along with distal 1/3 rd radius fracture on same side. Results: Rare case of patient with radial neck fracture and distal 1/3 rd radius fracture and its functional and anatomical outcome using intramedullary nailing and percutaneous pinning has excellent results. Conclusion: Closed reduction using Metaizeu procedure with kapandji and the percutaneous pinning results in excellent outcome.