The government has made various efforts to prevent and control COVID-19, such as enforcing the law concerning the COVID-19 Health Protocols. However, violations of health protocols still frequently occur in various circles, including university students. Therefore, this study aims to determine the factors that influence university students’ compliance with the COVID-19 health protocols. This study used a cross-sectional study design with a quota sampling technique and was conducted in October 2020. The participants were 468 university students in East Java. The number of participants who complied with the COVID-19 health protocols was 61.3%, while those who did not comply were still quite high (38.7%). The factors that were significantly related to compliance with the COVID-19 health protocols were knowledge, motivation, and health problems, while lifestyle changes were not significantly related to compliance with the COVID-19 health protocols. Participants with high level of knowledge (AOR 5.54 95% CI: 2.68-11.49), good motivation (AOR 2.15 95% CI: 1.43-3.22), and health problems (AOR 1.19 95% CI: 0.52-2.73) are more likely to comply with the COVID-19 health protocols. Thus,concerted efforts are needed to increase knowledge and motivation so that compliance with the COVID-19 health protocol significantly increases. Keywords: Knowledge, Motivation, Health Problems, Compliance Abstrak Pemerintah telah melakukan berbagai upaya pencegahan dan penanggulangan COVID-19 seperti penegakan hukum dengan Protokol Kesehatan COVID-19. Namun, pelanggaran terhadap protokol kesehatan masih sering terjadi di berbagai kalangan termasuk mahasiswa. Oleh karena itu, penelitian ini bertujuan untuk mengetahui faktor yang mempengaruhi kepatuhan protokol kesehatan COVID-19 pada mahasiswa. Penelitian ini menggunakan desain studi potong-lintang dengan teknik quota sampling dan dilakukan pada bulan Oktober 2020. Partisipan pada penelitian ini sebanyak 468 mahasiswa di Jawa Timur. Partisipan mahasiswa yang patuh terhadap protokol kesehatan COVID-19 sebesar 61,3%, sedangkan yang tidak patuh masih cukup tinggi (38,7%). Faktor yang berhubungan signifikan dengan kepatuhan protokol kesehatan COVID-19 adalah pengetahuan, motivasi, dan masalah kesehatan sedangkan perubahan gaya hidup tidak berhubungan signifikan dengan kepatuhan protokol kesehatan COVID-19. Partisipan dengan pengetahuan yang tinggi (AOR 5,54 95% CI: 2,68-11,49), motivasi baik (AOR 2,15 95% CI:1,43-3,22), dan memiliki masalah kesehatan (AOR 1,19 95% CI: 0,52-2,73) cenderung lebih patuh untuk terhadap protokol kesehatan COVID-19. Dengan demikian, diperlukan upaya yang terencana untuk meningkatkan pengetahuan dan motivasi supaya kepatuhan terhadap protokol kesehatan COVID-19 meningkat secara signifikan. Kata kunci: Pengetahuan, Motivasi, Masalah Kesehatan, Kepatuhan

Corona Virus Disease-19 (COVID-19) is the virus that causes an epidemic of acute respiratory infections that become a global pandemic in 2020. COVID-19 cases continue to increase, so prevention behavior is needed. Knowledge and attitudes become important domains that can influence a person's behavior. This study aims to determine the relationship between knowledge and attitudes related to COVID-19 prevention behaviors in university students. This study used a cross sectional study design which was conducted from April to May 2020. Students from the faculty of religion at UIN Syarif Hidayatullah Jakarta (n = 434) were participated in this study. As many as 51.4% (n = 223) of participants had a positive attitude towards preventing COVID-19. Participants who are well-behaved attitude towards COVID-19 prevention tend to have moderate and high levels of knowledge about COVID-19 and positive attitude (59.7%) towards COVID-19 prevention. The multivariate results showed that levels of knowledge and attitudes were related to COVID-19 prevention behaviors with adjustment for age, sex, and place of residence (p-value < 0.05). We conclude that knowledge and attitudes have an influence on a person's behavior in preventing the transmission of COVID-19. Abstrak Corona Virus Disease-19 (COVID-19) adalah virus penyebab wabah infeksi pernapasan akut yang menjadi pandemi global pada tahun 2020. Kasus COVID-19 terus mengalami peningkatan, sehingga diperlukan adanya perilaku pencegahan. Pengetahuan dan sikap menjadi domain penting yang dapat memengaruhi perilaku seseorang. Penelitian ini bertujuan untuk mengetahui hubungan pengetahuan dan sikap terkait COVID-19 dengan perilaku pencegahan COVID-19 pada mahasiswa. Studi ini menggunakan desain studi cross sectional yang dilakukan pada April–Mei 2020. Mahasiswa dari fakultas keagamaan UIN Syarif Hidayatullah Jakarta (n=434) adalah partisipan dalam penelitian ini. Sebanyak 51,4% (n=223) partisipan berperilaku positif terhadap pencegahan COVID-19. Partisipan yang berperilaku baik terhadap pencegahan COVID-19 cenderung memiliki tingkat pengetahuan yang sedang dan tinggi tentang COVID-19 dan sikap positif (59,7%) terhadap pencegahan COVID-19. Hasil multivariat menunjukkan bahwa tingkat pengetahuan dan sikap berhubungan dengan perilaku pencegahan COVID-19 dengan penyesuaian variabel usia, jenis kelamin, dan tempat tinggal (nilai p-value < 0,05). Kami menyimpulkan bahwa pengetahuan dan sikap memiliki pengaruh pada perilaku seseorang dalam mencegah COVID-19.