Ajwain, dried mature seed like fruits are well known by names such as thymol seeds, caraway, carom, ajowan, or bishop's weed, belongs to the Apiaceae family. Carum copticum is the Latin name for this spice. Trachyspermum ammi (L.) Sprague ex Turrill is scientific name. This spice is indigenous to Egypt, although it is also cultivate in India, Iran, Pakistan, Iraq, Afganistan, other nations in South and West Asia as well as Europe. Gujarat and Rajasthan are Indian states noted for their ajwain cultivation. It is known as Zenyan or Nankhah in medical and pharmaceutical manuscript of medieval Persia. As Traditional Persian Medicine, Ajwain was well known from thousands of years in unani as well as ayurveda. It is used as a spice world-widely. This plant contains a variety of bioactive compunds of pharmacological importance, involving carbohydrates, fat, fibre, glycosides, protein, phenolic compounds, volatile oil (thymol, γ-terpinene, para-cymene, and α-and β-pinene), saponins and mineral content are found in this plant. The ajwain extract is known as "Admoda Arka" in Ayurveda. Ethnopharmacological values added by Vaidya gurus for coughs, colds, pain, headaches, heartburn, asthma, diarrhoea, painful menstruation, cholera, stomach discomfort, and smooth respiratory and kidney function. It has been used in modern medicine due to clinical findings of its pharmacological activities involving Bronchodilator, Cardiac Stimulant, Carminative, Digestive Stimulant, Diuretic, Galactagogue, Hypo-glycemic, Antioxidant, Antifungal, Anthelmintic, Anti-arthritic, Anti-inflammatory, Antiflatulent, Analgesic, Antimicrobial, Antihypertensive, Antifilarial. In this paper we primarily focused on Detailed phytochemistry along with Pharmcognostical and Nutritional values, also traditional and modern pharmacological role along with its safety measurement.