The nanoparticles of Cobalt ferrite are synthesized using polyethylene glycol as a solvent by the solvothermal method in a surfactant-free condition. Nanoparticles that were synthesized were determined by using various techniques such as Diffuse Reflection Spectroscopy (DRS), X-Ray Diffraction (XRD), Scanning Electron Microscope (SEM), and Energy Dispersive X-ray spectroscopy (EDAX). The Scanning electron microscope confirmed the range of spherical nanoparticles in the size of 20–33 nm. An excellent match was observed between the calculated particles size in the X-ray diffraction and electron microscopes results. Furthermore, their antimicrobial efficacy was determined by MIC, MBC, IC50 and disc diffusion method on Gram-negative ( Pseudomonas aeruginosa and Escherichia coli ) and Gram-positive ( Staphylococcus aureus, Bacillus cereus ) bacteria. The results indicated an acceptable bacteriostatic and bactericidal effects of this nanoparticles. Additionally, it was seen that by the increase in the concentration of nanoparticles, their antimicrobial property would increase. Background and objective In recent years, antibacterial materials have found a special place to avoid the overuse of antibiotics. In this study, the antibacterial effects of CoFe 2 O 4 nanoparticles on Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Bacillus cereus, were investigated due to their importance as human pathogens in nosocomial infection. Methodology In this study, the antibacterial effects of CoFe 2 O 4 nanoparticles such as MIC, MBC, IC50, and disc diffusion method were examined. Findings According to the results, CoFe 2 O 4 nanoparticles exhibited potent antibacterial activity against the bacteria that were examined, especially Bacillus cereus . The MBC (Minimum Bactericidal Concentration) of CoFe 2 O 4 nanoparticle on Escherichia coli , Staphylococcus aureus , Pseudomonas aeruginosa , Bacillus cereus was between 0.12-0.48 mg/ml and MIC (Minimum Inhibition Concentration) on these bacteria detected between 0.06-0.24 mg/ml. The least IC50 determined for Bacillus cereus with a concentration of 0.061 mg/ml. Pseudomonas aeruginosa and Bacillus cereus identified as the most resistant and sensitive bacteria in the disc diffusion method, respectively.

Quinazoline-2,4(1H,3H)-dione is a significant class of N-fused heterocyclic with a wide range of biological functions, including anti-HIV, anticancer,

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The antibacterial properties of CFO/BiOI nanocomposite were investigated in our current study because of their importance in Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Bacillus cereus. MIC, MBC, Disk Diffusion, and IC50 tests cefalotin (CF), amoxicillin (AMX), gentamicin (GM), Trimethoprim‐sulphamethoxazole (SXT), and Ceftriaxone (CRO) antibiotics in concentration 30, 10, 10, 25, and 30  μg were used, respectively. Various techniques such as X‐ray diffraction (XRD), scanning electron microscope (SEM), high‐resolution mapping, and energy dispersive X‐ray spectroscopy (EDAX) have been used to determine the properties of produced nanocomposites. The results showed CFO/BiOI nanocomposite exhibits strong significant biological activity against B. cereus. The results of MBC (minimum bactericidal concentration) and MIC (Minimum Inhibition Concentration) tests for CFO/BiOI nanocomposites on bacteria were examined in the range of 0.12–0.48 and 0.06 to 0.24 mg ml−1, respectively. According to the results,, the minimum IC50 value was determined at a concentration of 0.061 mg ml−1. On the other hand, the most resisting and susceptible bacteria in this method were P. aeruginosa and B. cereus, respectively. These findings are identical to a prior study on antibacterial properties of CoFe2O4 nanoparticles. The MBC endpoint is defined as the lowest concentration, which killed 98% of the bacterial population.

With the increase of general knowledge and the advancement of science and technology, antibacterial substances were used more than antibiotics. In our current study, the antibacterial virtues of CFO/BiOI nanocomposite were investigated due to its high importance on Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Bacillus cereus. MIC, MBC , Disk Diffusion and IC50 tests Cefalotin (CF), Amoxicillin (AMX), Gentamicin (GM), Trimethoprim-sulphamethoxazole (SXT) and Ceftriaxone (CRO) antibiotics in concentration 30W, 10i, 10t , 25h and 30 were used to find the antibacterial properties of the synthesized nanocomposite, respectively. For the synthesis of nanocomposites polyethylene glycol (PEG) and sulfonic acid was used as a solvent. It is noteworthy that the synthesis was performed by heat dissolution method without the presence of surfactant. Also, various techniques such as X-Ray Diffraction(XRD), Scanning Electron Microscope (SEM), High resolution mapping and Energy Dispersive X-ray spectroscopy (EDAX) have been used to determine the properties of produced nanocomposites. SEM test results showed that the formed nanoparticles were globular and their size was limited area of 22 to 34 nm. The results showed CFO / BiOI nanocomposite exhibits strong significant biological activity against Bacillus cereus. The results of MBC (Minimum Bactericidal Concentration) and MIC (Minimum Inhibition Concentration) tests for CFO/BiOI nanocomposites on bacteria were examined in the range of 0.12-0.48 mg/ml and 0.06 to 0.24 mg/ml respectively. According to the results, the minimum IC50 value was determined at a concentration of 0.061 mg/ml. On the other hand, the most resisting and susceptible bacteria in this method were Pseudomonas aeruginosa and Bacillus cereus, respectively. These findings are identical to those of a prior study on CoFe2O4 nanoparticles antibacterial properties. MBC of the nanocomposites, 50 µl from all the tubes that showed no obvious bacterial growth were distributed on BHI agar plates and incubated for 24 h at 37 ◦C. The MBC endpoint is defined as the lowest concentration which killed 98% of the bacterial population.