Background:The goal of head nurses is to achieve patient safety, which is considered a critical component of quality health care. Aim: To assess the effect of applying a training program about international patient safety goals on patient's safety culture at Rajhy Liver Hospital, Assiut University. Subject and method: A quasi-experimental design used to conduct this study. The study subjects included all head nurses (n=29) from different health care units. The data collection tool included three tools: I. Personal data questionnaire, II. Head nurses management regarding patient's safety questionnaire, and III. Hospital survey on patient's safety culture questionnaire. Results: there was a highly statistically significant difference with a strong positive correlation impact between head nurses' management regarding applying international patient safety goals using the PDCA model and patient's safety culture. Conclusion:The implementation of a training program is successful and effective in improving head nurses' management regarding applying international patient safety goals using the PDCA model after implementing the training program. Recommendations: The continuous training program and development activities about international patient safety goals should be applied to all head and staff nurses in the study setting, and extended to other similar settings.