Background. Iranian traditional medicine (ITM) is a holistic medical system that uses a wide range of medicinal substances to treat disease. Reorganization and standardization of the data on ITM concepts is a necessity for optimal use of this rich source. In an initial step towards this goal, we created a database of ITM materia medica. Main Body. Primarily based on Makhzan al-Advieh, which is the most recent encyclopedia of materia medica in ITM with the largest number of monographs, a database of natural medicinal substances was created using both text mining methods and manual editing. UNaProd, a Universal Natural Product database for materia medica of ITM, is currently host to 2696 monographs, from herbal to animal to mineral compounds in 16 diverse attributes such as origin and scientific name. Currently, systems biology, and more precisely systems medicine and pharmacology, can be an aid in providing rationalizations for many traditional medicines and elucidating a great deal of knowledge they can offer to guide future research in medicine. Conclusions. A database of materia medica is a stepping stone in creating a systems pharmacology platform of ITM that encompasses the relationships between the drugs, their targets, and diseases. UNaProd is hyperlinked to IrGO and CMAUP databases for Mizaj and molecular features, respectively, and it is freely available at http://jafarilab.com/unaprod/.

: Freckles are common pigmented lesions frequently observed on the face and other sun-exposed areas of the skin. Ephelides have an autosomal dominant inheritance, indicating that melanocyte activity and sun exposure are significant risk factors for the development of these lesions. The importance of freckles can be discussed from two perspectives of cosmetics and their complications. This research is the first step in gaining access to extensive scientific and experimental resources of Persian medicine (PM). "Barash" and "Namash" are the equivalent terms for freckles in medieval manuscripts of Persia. Therefore, words related to "Barash & Namash" from PM ancient manuscripts and other relevant keywords were searched in Google Scholar, PubMed, and Scopus databases. Extracted results were subsequently compared and recorded under the following classification. The clinical symptoms of freckles were similar to those of "Namash & Barash" diseases. Different therapeutic methods to treat such diseases in PM include lifestyle modification, medication, and manual intervention. There are several preventive and therapeutic methods for the management of freckles. Further research is required in this regard to identify more academic evidence.