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Objectives: To determine the efficacy of fetal stem cell transplant for treating patients with diabetes mellitus types 1 and 2. Materials and Methods: Five patients with diabetes mellitus type 1 and 5 patients with diabetes mellitus type 2 (aged 18-56 years) received a fetal pancreatic stem-cell transplant (cells were 16-18 wk gestation) performed by intravenous infusion at 50 mL/hour. The quantity of fetal stem cells infused was ≥ 5-8*10⁶. We analyzed the patients' C-peptide and glycated hemoglobin levels both before and 3 months after fetal stem cell transplant. Results: In patients with diabetes mellitus type 1, fetal stem-cell transplant led to a significant increase in C-peptide levels, from 0.09 ± 0.01 ng/mL to 0.20 ± 0.07 ng/mL, after 3 months (P < .008). Conclusions: Treatment with fetal pancreatic stem cells may be beneficial for treating patients with type 1 or type 2 diabetes.

Conclusion:Findings suggest that patients receiving FPCT had a 48% lower risk of all-cause death. We also reveal better outcomes for the FPCT group regarding CHD, retinopathy, nephropathy, neuropathy, and diabetic foot, however, the EPCT group had a higher risk of nephropathy. Further investigations involving clinical and laboratory data are warranted.

Background: The expression of vitamin D receptor in the normal endometrium and ovaries supports the role of vitamin D in local immunity and inflammatory cytokines regulation. Objective: This study aimed to detect the relation between serum 25(OH)D and primary dysmenorrhea. Methods: Two hundred and five (205) adolescents complaining of primary dysmenorrhea (study group) were compared with matched controls (210 controls), after informed consent following the Helsinki Declaration. After thorough evaluation, and pelvic ultrasound examination, blood samples were collected from the studied adolescents for measuring the serum 25(OH)D and for vitamin D receptor TaqI (rs731236) genotyping. Collected data were analyzed using the Pearson`s correlation to detect the relation between serum 25(OH)D and primary dysmenorrhea (primary outcome). The secondary outcome measures the odds of primary dysmenorrhea in Asian adolescents with TaqI (rs731236) polymorphism. Results: The serum 25(OH)D was significantly lower in the studied-dysmenorrhea group compared to controls (16.17 ± 7.36 versus 17.65 ± 6.36 ng/ml, respectively), (P=0.01). The correlation analysis showed a significant negative correlation between the serum 25(OH)D, and visual analogue scale of dysmenorrhea (r=-0.9003, P<0.0001). The studied-dysmenorrhea cases with T/t and t/t genotypes had significantly lower serum 25(OH)D (16.7 ± 8.05 and 14.4 ± 4.1 ng/ml, respectively) compared to controls (18.97 ± 6.7 and 21.4 ± 2.45 ng/ml, respectively), (P=0.02 and 0.004, respectively). The odds of primary dysmenorrhea were significantly higher in T/t and t/t genotypes (OR 1367.2, P<0.0001, and 106.2, P=0.001, respectively). Conclusion: The serum 25(OH)D was significantly lower in the studied-dysmenorrhea group compared to controls. The studied-dysmenorrhea cases with T/t and t/t TaqI genotypes had significantly lower serum 25(OH)D compared to controls. The odds of primary dysmenorrhea were significantly higher in T/t and t/t TaqI genotypes.