A facile one-pot four-component reaction was utilized to construct 2-oxo-1,2-dihydropyridine-3-carbonitrile as a scaffold for the synthesis of many fused heterocyclic systems, namely, furopyridine, pyridothiadiazepinthione, and pyridotriazine, as well as non-fused heterocyclic systems such as phthalazin-2(1H)-ylnicotinonitrile, pyridin-2-yl-1H-pyrazole, and pyrazol-1-ylnicotino-nitrile,1-(3-cyanopyridin-2-yl)-1H-pyrazole. The new compounds were evaluated as antimicrobial and antiviral agents.

Pyridine Moiety. -A variety of heterocycles containing the pyridine moiety is prepared starting from (IV) and (IX). Some of them are evaluated for their antibacterial and antiviral activities. (VII) and (IX) show promising antiviral activity towards rotavirus Wa strain and adenovirus type 7 and possess antibacterial effect towards S. aureus and E. coli. -(SALEM*, M. S.; SAKR, S. I.; EL-SENOUSY, W. M.; MADKOUR, H. M. F.; Arch. Pharm. (Weinheim, Ger.) 346 (2013) 10, 766-773, http://dx.