Background: Gout is the most prevalent inflammatory arthritis in the Asia-Pacific region and worldwide. This clinical practice guideline (CPG) aims to provide recommendations based on systematically obtained evidence and values and preferences tailored to the unique needs of patients with gout and hyperuricemia in Asia, |LORENZO Et aL. | INTRODUC TI ONGout is the most prevalent inflammatory arthritis in the Asia-Pacific region and worldwide. 1 Its prevalence increased steadily in various countries: 2.7% in the 1990s to 3.9% in early 2000 in the United States and from 3.4 per 1000 in 2007 to 7.6 per 1000 persons in 2015 in Korea. 2,3 The prevalence is higher in certain ethnic groups.The risk for tophi formation tends to be higher after controlling for age, gender, hypertension, diuretic use, and kidney function. 4 Varying prevalence across ethnic groups indicates that genetics affects its development and the individual's risk when exposed to environmental or dietary variables. 5,6 Despite scientific advancements, disease control of gout is suboptimal. 2,3 Clinical practice guidelines (CPG) from Western and several Asian countries have provided recommendations for the management of gout. [7][8][9] However, the need to formulate unified Asia-Pacific recommendations was recognized. This CPG aims to provide evidence-based recommendations in managing gout in its different phases: asymptomatic hyperuricemia, acute gout, intercritical gout, and chronic tophaceous or complicated gout. It covers both pharmacologic and non-pharmacologic interventions (NPI) with consideration of the unique needs of patients with gout in Asia, Australasia, and the Middle East. The target users of these guidelines are general practitioners and specialists, including rheumatologists, in different clinical settings in these regions. | G UIDELINE DE VELOPMENT ME THODSThe Steering Committee (SC) formed the guideline development working groups (GDG), formulated the guideline questions (Table 1) in PICO (population, intervention, comparator, and outcome) format, and oversaw the CPG processes (Figure 1). The Technical Working Group (TWG) appraised and summarized the evidence, applied the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology to determine the certainty of evidence, and drafted the recommendations.The Consensus Panel (CP) was composed of 9 key stakeholders (rheumatologists, general practitioners, academicians, and a patient representative) from Australia,

CFD simulation of heat transfer and friction factor characteristics in a circular tube fitted with twisted tape inserts in laminar flow and constant heat flux is conducted using FLUENT version 6.3.26. Plain and alternate axis twisted tape inserts with twist ratios (y = 2.93, 3.91, 4.89) and alternative angles (β = 30°, 60°, 90°) have been used for the simulation. The simulated results are matched with the literature correlations for a plain tube with a discrepancy of less than ±8% for Nusselt number and ±6.25% for friction factor. The results also revealed that the heat transfer in terms of the Nusselt number increased with increases of Reynolds number, alternative angles, and decreases of twist ratio. Among the various twist ratios and alternative angles, the twist ratio of y = 2.93 and alternative angle β = 90° offered a maximum heat transfer enhancement. © 2013 Wiley Periodicals, Inc. Heat Trans Asian Res, 43(4): 384–396, 2014; Published online 3 October 2013 in Wiley Online Library (http://wileyonlinelibrary.com/journal/htj). DOI 10.1002/htj.21089

This study presents, a numerical investigation of two‐dimensional turbulent nanofluids flow in different ribs tube configurations on heat transfer, friction, and thermal performance coefficients using ANSYS‐FLUENT software version‐16. Governing equations of mass, momentum, and energy have been solved by means of a finite volume method (FVM). Four types of nanoparticles namely; Al2O3, CuO, SiO2, and ZnO with volume fraction range (1%‐4%) and different size of nanoparticles (dp = 30 nm, 40 nm, 50 nm, and 60 nm) with various Reynolds number (10 000‐30 000) in a constant heat flux tube with rectangular, triangular, and trapezoidal ribs were conducted for simulation. The results exhibit that Nusselt number for all cases enhanced with Reynolds number and nanofluid volume fraction increases. Likewise, the results also reveal that SiO2 with volume fractions of 4% and diameters of nanoparticles of 30 nm in triangular ribs offered the highest Nusselt number at Reynolds number of Re = 30 000. In addition, the higher value of thermal performance factor was obtained at Reynolds number of Re = 10 000.

Numerical investigation of the heat transfer and friction factor characteristics of a circular fitted with V-cut twisted tape (VCT) insert with twist ratio (y = 2.93) and different cut depths (w = 0.5, 1, and 1.5 cm) were studied for laminar flow using CFD package (FLUENT-6.3.26). The data obtained from plain tube were verified with the literature correlation to ensure the validation of simulation results. Classical twisted tape (CTT) with different twist ratios (y = 2.93, 3.91, 4.89) were also studied for comparison. The results show that the enhancement of heat transfer rate induced by the classical and V-cut twisted tape inserts increases with the Reynolds number and decreases with twist ratio. The results also revealed that the V-cut twisted tape with twist ratio y = 2.93 and cut depth w = 0.5 cm offered higher heat transfer rate with significant increases in friction factor than other tapes. In addition the results of V-cut twist tape compared with experimental and simulated data of right-left helical tape inserts (RLT), it is found that the V-cut twist tape offered better thermal contact between the surface and the fluid which ultimately leads to a high heat transfer coefficient. Consequently, 107% of maximum heat transfer was obtained by using this configuration.