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The presence of glomerular IgE deposits (IgE+) and its prognostic significance were examined in 241 patients with various renal diseases. 24 patients (10%) had IgE+, and nephrotic syndrome was present in 22 (92%). 17 of the 24 patients with IgE+ had lupus nephritis. These patients were compared with another group of 32 patients with lupus nephritis, but without IgE deposits (IgE-). Light and electron microscopy showed more severe pathological changes in those with IgE+ than in patients who were IgE-. The number of patients who displayed deterioration in renal function was greater in the former group than in the latter (70 vs. 31 %). Our results show that (1) nephrotic syndrome is very common among patients with IgE+; (2) the incidence of IgE deposits in lupus nephritis patients is high (35%) and the incidence of lupus nephritis among patients with IgE deposits is 71 %, and (3) the presence of IgE deposits in patients with lupus nephritis may carry a bad prognosis. It is suggested that immunofiuorescent studies of renal biopsies should include the evaluation of IgE deposition.

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Renal handling of salt and water during water diuresis was studied in the same 7 healthy subjects before and after the administration of tolinase. After tolinase there was no change in mean values of C_inulin, C_{p-aminohipurate} and calculated rate of distal sodium delivery (CH₂O + C_Na/100 ml glomerular filtration rate). Mean filtration fraction fell from 19.3 ± SD3.5to 16.8 ± 3.3% (p < 0.01). The mean fraction of delivered sodium reabsorbed at the diluting site (CH₂O/[CH₂O + C_Na]) rose from 83.3 ± SD 3.6 to 88.0 ± 3.3% (p < 0.05). Mean minimal urinary osmolality fell from 85.9 ± SD 8.6 to 69.4 ± 10.3 mOsm/kg H₂O (p < 0.01). Free water clearance for a given rate of urine flow was higher following tolinase than in controls. Mean rate of urinary potassium excretion fell following tolinase (p < 0.05). Maximal urinary concentration following 24 h fluid deprivation was unchanged by tolinase either in man or in the dog. Augmented tubular reabsorption of sodium at the diluting site appears to underly the lowering of minimal urinary osmolality following tolinase.