Glomerular IgE Deposits in Patients with Lupus Nephritis

Tuma, Samir; Llach, Francisco; Sostrin, Stuart; Dubois, E L; Massry, Shaul G.

doi:10.1159/000166485

Cited by 19 publications

(18 citation statements)

References 6 publications

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“…A possible pathogenic role of IgE antibodies in lupus nephritis has been claimed by some research groups that observed an increased serum concentration of this immunoglobulin in renal SLE patients (4,10). Additionally, IgE was detected in glomerular deposits of immune complexes by immunofluorescence assays of kidney biopsies from renal SLE subjects (18,19). In the present study, 5 of 8 SLE patients with laboratory findings of renal disorders such as proteinuria, hematuria and urinary cellular casts had high serum IgE concentrations and 6 of them had antinuclear IgE autoantibodies.…”

supporting

confidence: 51%

Immunoglobulin E and systemic lupus erythematosus

Atta

Sousa

Carvalho

et al. 2004

Braz J Med Biol Res

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Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by intense polyclonal production of autoantibodies and circulating immune complexes. Some reports have associated SLE with a Th2 immune response and allergy. In the present study 21 female patients with SLE were investigated for total IgE and IgE antibodies to dust house aeroallergens by an automated enzymelinked fluorescent assay, and were also evaluated for antinuclear IgE autoantibodies by a modified indirect immunofluorescence test using HEp-2 cells as antigen substrate. Additionally, immunocapture ELISA was used to investigate serum anti-IgE IgG autoantibodies. Serum IgE above 150 IU/ml, ranging from 152 to 609 IU/ml (median = 394 IU IgE/ml), was observed in 7 of 21 SLE patients (33%), 5 of them presenting proteinuria, urinary cellular casts and augmented production of anti-dsDNA antibodies. While only 2 of 21 SLE patients (9.5%) were positive for IgE antibodies to aeroallergens, all 10 patients with respiratory allergy (100%) from the atopic control group (3 males and 7 females), had these immunoglobulins. SLE patients and healthy controls presented similar anti-IgE IgG autoantibody titers (X = 0.37 ± 0.20 and 0.34 ± 0.18, respectively), differing from atopic controls (0.94 ± 0.26). Antinuclear IgE autoantibodies were detected in 17 of 21 (81%) sera from SLE patients, predominating the fine speckled pattern of fluorescence, that was also observed in IgG-ANA. Concluding, SLE patients can present increased IgE levels and antinuclear IgE autoantibodies without specific clinical signs of allergy or production of antiallergen IgE antibodies, excluding a possible association between SLE and allergy.

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supporting

confidence: 51%

Immunoglobulin E and systemic lupus erythematosus

Atta

Sousa

Carvalho

et al. 2004

Braz J Med Biol Res

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“…The latter authors state that, through the release of vasoactive mediators from basophils and mast cells, IgE can cause increased vasopermeability, which may be important in causing the deposition of circulating immune complexes in glomerulonephritis pathogenesis (28),(29). The demonstration of increased IgE serum levels in SLE patients with renal involvement and the detection of IgE immune complex deposition in renal biopsies further implicate IgE in the pathogenesis of lupus nephritis (13),(29),(30). High IgE levels have also been reported in adult SLE patients without nephritis, suggesting that IgE may have a role in SLE disease and not only in nephritis (4),(12),(14),(15),(31),(32).…”

Section: Discussionmentioning

confidence: 91%

Increased IgE serum levels are unrelated to allergic and parasitic diseases in patients with juvenile systemic lupus erythematosus

Liphaus¹,

Jesus²,

Silva³

et al. 2012

Clinics

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OBJECTIVE:The aim of this study was to assess the IgE serum levels in juvenile systemic lupus erythematosus patients and to evaluate possible associations with clinical and laboratory features, disease activity and tissue damage.METHODS:The IgE serum concentrations in 69 consecutive juvenile systemic lupus erythematosus patients were determined by nephelometry. IgG, IgM and IgA concentrations were measured by immunoturbidimetry. All patients were negative for intestinal parasites. Statistical analysis methods included the Mann-Whitney, chi-square and Fisher's exact tests, as well as the Spearman rank correlation coefficient.RESULTS:Increased IgE concentrations above 100 IU/mL were observed in 31/69 (45%) juvenile systemic lupus erythematosus patients. The mean IgE concentration was 442.0±163.4 IU/ml (range 3.5-9936.0 IU/ml). Fifteen of the 69 patients had atopic disease, nine patients had severe sepsis and 56 patients presented with nephritis. The mean IgE level in 54 juvenile systemic lupus erythematosus patients without atopic manifestations was 271.6±699.5 IU/ml, and only nine of the 31 (29%) patients with high IgE levels had atopic disease. The IgE levels did not statistically differ with respect to the presence of atopic disease, severe sepsis, nephritis, disease activity, or tissue damage. Interestingly, IgE concentrations were inversely correlated with C4 levels (r = -0.25, p = 0.03) and with the SLICC/ACR-DI score (r = -0.34, p = 0.005). The IgE concentration was also found to be directly correlated with IgA levels (r = 0.52, p = 0.03).CONCLUSIONS:The present study demonstrated for the first time that juvenile systemic lupus erythematosus patients have increased IgE serum levels. This increase in IgE levels was not related to allergic or parasitic diseases. Our results are in line with the hypothesis that high IgE levels can be considered a marker of immune dysregulation.

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“…Other antisera which have been used include those to IgE [247], kappa and lambda lights chains, renal tubular components, hepatitis B antigen, DNA, properdin, carcinoembryonic antigen, various bacterial and parasitic antigens and several components of the complement system, particularly Clq [137,248]. A control specimen of renal tissue with known staining characteristics should be included with each procedure.…”

Section: Methodsmentioning

confidence: 99%