Pancreas transplantation (PTx) is a curative treatment for people who live with the burden of a diagnosis of diabetes mellitus (DM). However, due to organ shortages and increasing numbers of patients being listed for PTx, new strategies are needed to increase the number of available grafts for transplantation.Static cold storage (SCS) is considered the gold standard for standard criteria organs.However, standard criteria donors (SCD) are becoming scarce and new strategies that can increase the rate of organ acceptance from extended criteria donors (ECD) are urgently needed.Normothermic ex vivo perfusion (NEVP) is one of the strategies that has become increasingly popular over the past couple of decades. This preservation method has already been used successfully in other organs (liver, kidneys, and lungs) but has been minimally explored in pancreas transplantation. The few papers that describe the method for pancreas show little success, edema being one of the major issues. The following manuscript describes the successful NEVP method and setup developed by our group to perfuse swine pancreas.

No abstract

No abstract

Decompensated chronic liver disease is the 14th leading cause of mortality in adults. It includes many aetiologies, some of which are treatable and preventable, whereas others are not. It is a progressive disease, resulting in various manifestations such as portal hypertension, hepatorenal syndrome, portopulmonary hypertension, ascites, spontaneous bacterial peritonitis (SBP), variceal bleeding and cardiomyopathy, which unless treated, result in end-stage liver failure requiring liver transplantation as treatment. In the present article, we review its aetiopathogenesis, clinical features and the current guidelines recommended for its treatment from a high volume tertiary care centre in India.