The pedicles act as struts and reinforce the vertical system of columns. The pedicle as this is the site where vertebral column fixation surgeries are most frequently implemented. Objective: This study has been attempted to find out the transmission of weight through pedicles in man of South Karnataka region, India so that this knowledge could be applied to explain some of the clinicopathological conditions of the spine. Materials and Methods: The 6 cervical and upper 5 thoracic vertebrae of 30 human adult male columns were selected for the study. The various parameters of inferior body surface area, pedicle index, body-pedicle angle and the ratio pedicle index to inferior body surface area were measured for each of the 6 cervical and upper 5 thoracic vertebrae of 30 columns. Results: The area of the inferior surface of T 5 vertebra was more than double that of the body of C 2 vertebra. The mean pedicle index was greater at C 2 , T 1 , and T 2 levels, while it was smaller at the remaining levels. At C 2 level, in relation to the body, pedicles were directed backwards, downwards and laterally while, at C 4 level, pedicles were almost directed horizontal. From C 6 level downwards, pedicles were directed upwards and backwards. Their lateral deviation gradually diminished and at T 5 , it was directed completely backwards. Conclusion: The measurements obtained by the present study reveals the importance of pedicle in understanding the mechanics of spinal anatomy and its applications with respect to transmission of weight.