BackgroundSalmonella species are among the most common food borne pathogens worldwide and their infection is one of the major global public health problems. During the last decade, multidrug resistant Salmonella species have greatly increased in humans and animals. So the aim of this study was to determine prevalence and antibiotic susceptibility pattern of Salmonella in apparently healthy slaughterer cattle and personnel working at the Jimma abattoir.MethodA cross-sectional study was conducted from May to September 2016 at the Jimma abattoir. A total of 440 samples consisting of carcass swabs (n = 195), cattle feces (n = 195), and human stool (n = 50) were collected. Standard isolation and identification procedures were performed to identify Salmonella isolates. Antimicrobial susceptibility tests were also carried out on each isolate.ResultsThe overall proportion of Salmonella positive isolates was 9.5% in all samples, of which 11.3% were from carcass swabs, 5.6% from cattle feces, and 18% from human stool. All isolates were resistant to tasted antibiotics except Ciprofloxacin.ConclusionThis study ascertains that Salmonella were widely distributed and significant proportions have developed resistance to routinely prescribed antibiotics. Therefore, there is needed to implement urgent intervention programs in study area.