This work describes a series of investigations carried out on sets of pristine and auxetic (negative Poisson's ratio (NPR)) open‐cell polyurethane foams subjected to relative humidity (RH) conditioning ranging from 9% to 92% at room temperature. The foams have been produced using a uniaxially thermoforming process. Pristine and auxetic foams have then been subjected to quasi‐static compressive cyclic loading (with maximum strains of 10% and 80%, respectively), as well as vibration transmissibility tests with base accelerations up to 2.29 g. Increasing levels of RH do not seem to statistically affect the moduli and PRs of foams subjected to lower maximum strains, however, especially the auxetic foams at higher compressive deformations show a decrease in the stiffness with the increase of the RH. The vibration tests show an increasing trend of the dynamic modulus of the foams with the increase of the RH. The results indicate the complexity of the interaction between foam architecture and absorption/desorption mechanisms occurring inside these porous auxetic materials.