Carbonylation of (hetero)­aryl iodides/bromides with highly deactivated 2-aminopyridines using Pd–Co­(CO)4 bimetallic catalysis is accomplished. The use of Co2(CO)8 as a solid CO­(g) source enhanced reaction rates observed when compared to CO­(g), and excellent yields highlight the versatility of the developed protocol. A wide range of electronically and sterically demanding heterocyclic amines and (hetero)­aryl iodides/bromides employed for this study resulted in excellent yields of amino carbonylated products. The developed methodology was further extended to synthesize Trypanosome brucie and luciferase inhibitors.

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A mild and versatile method for the efficient construction of heterocyclic framework of meridianins from simple precursors has been devised. The strategy involves the assembly of the pyrimidine ring utilizing the nucleophilicitiy of monothio-1,3-diketone formed by thioacylation at the C-3 in the indole ring.