Carbonylation of (hetero)­aryl iodides/bromides with highly deactivated 2-aminopyridines using Pd–Co­(CO)4 bimetallic catalysis is accomplished. The use of Co2(CO)8 as a solid CO­(g) source enhanced reaction rates observed when compared to CO­(g), and excellent yields highlight the versatility of the developed protocol. A wide range of electronically and sterically demanding heterocyclic amines and (hetero)­aryl iodides/bromides employed for this study resulted in excellent yields of amino carbonylated products. The developed methodology was further extended to synthesize Trypanosome brucie and luciferase inhibitors.

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Contents:1General Experimental Details 1 2 General Procedure for the synthesis of o-ureidobenzonitriles (3a-3t) 2 3 Characterization details of the synthesized Products 3 -13 4 1 H-NMR, 13 C-NMR and HRMS Spectra 14 -46 5 Crystal analysis data 47-49

An expedient, efficient, economical, environmentally benign, and solvent-free amidation protocol of benzhydrols with less reactive nitrogen nucleophiles assisted by propylphosphonic anhydride (T3P®) under microwave irradiation has been developed. The methodology...

Contents 1 General Experimental Details 2 2 General Procedure for the synthesis of 1-(3-cyanothiophen-2-yl)-3-phenylurea derivatives (6a-6t) 3 3 Characterization details of the synthesized Products 4 -11 4 Spectra for the synthesized compounds