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Octenidine, a bispyridine antimicrobial compound, has evidenced significant antiplaque activity when used in solution in both animal and human model systems. The present study was designed to evaluate concurrently the antiplaque and antigingivitis potential of a dentifrice formulation containing octenidine. In addition to an antimicrobial agent, the product was formulated to exhibit abrasive and foaming chracteristics similar to those of current commercial dentifrices. Adult female cynomolgus monkeys, five per group, received once daily oral treatments with either the octenidine dentifrice formulation or a placebo formulation. Both formulations were delivered as a suspension which was gently dispersed by manipulation of the cheeks. Direct delivery using a toothbrush was purposely avoided in order to permit the assessment of antimicrobial and antiplaque efficacy in the absence of direct mechanical action. The development of plaque and gingivitis was observed to be suppressed in the presence of the octenidine dentifrice formulation over the 21‐day experimental period. By contrast, animals receiving the placebo formulation evidenced a signficant increase in dental plaque levels and extensive gingival inflammation.

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