The effect of daily treatments with an octenidine dentifrice formulation on gingival health in Cynomolgus monkeys

Slee, Andrew M.; Cimijotti, E.; Rothstein, Sanford S.

doi:10.1111/j.1600-0765.1985.tb00838.x

Cited by 4 publications

(6 citation statements)

References 20 publications

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“…This model bas been used to test the efficacy of agents to prevent the accumulation of plaque and thereby delay the onset of gingivitis during 21 days of tootbbrushing abstention. Mouthwashes containing Chlorhexidine (7), Oetenidine (8) and Sanguinarine (9), as well as a phenolic mouthwash (10) have been demonstrated to delay the onset of gingivitis. Tbese same materials were later shown to have gingival health benefits in longer term studies combining both mouthrinsing and normal toothbrushing (11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis

Saxton

Ouderaa

1989

J of Periodontal Research

142

127

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A partial mouth experimental gingivitis model was employed to establish the potential efficacy of a dentifrice containing a zinc salt and the antimicrobial agent Triclosan to prevent or delay the development of gingivitis over a period of 28 days. Initially, gingival health was established in 34 subjects following a 6-week period of professional tooth cleaning and oral hygiene instruction. A toothshield was constructed to fit 4 posterior mandibular teeth. Undiluted test or placebo dentifrice was applied to the experimental teeth via the toothshield, which also prevented plaque removal from these teeth during habitual brushing of the remainder of the dentition. The presence of plaque, bleeding after probing and visual signs of inflammation were independently assessed. Plaque accumulated rapidly and gingivitis developed in both groups. At the 2-wk assessments, lower mean plaque scores were recorded for the group using the test dentifrice. At the 4-wk assessment a significantly lower level of gingivitis was recorded for the test group. It is concluded that (a) the model can be used to establish the potential efficacy of a dentifrice to maintain gingival health, (b) the dentifrice containing zinc citrate and Triclosan was efficacious and (c) the Gingival Index possibly overestimates the proportion of healthy gingival sites.

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Section: Introductionmentioning

confidence: 99%

The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis

Saxton

Ouderaa

1989

J of Periodontal Research

142

127

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“…In dental practice, the main usage of OCT is as a mouth rinse material and the antimicrobial/ antiplaque effect thereof has been demonstrated in several studies. [16][17][18][19][20][21][22] It is reported that OCT inhibits dental plaque and caries in rats, dental plaque in primates, and in humans. [16][17][18][19] Pitten and Kramer 20 showed that OCT has antimicrobial efficiency in oral cavities.…”

Section: Discussionmentioning

confidence: 99%

“…[16][17][18][19][20][21][22] It is reported that OCT inhibits dental plaque and caries in rats, dental plaque in primates, and in humans. [16][17][18][19] Pitten and Kramer 20 showed that OCT has antimicrobial efficiency in oral cavities. On the other hand, Shern et al 17 compared OCT and CHX as a mouth rinse solution in rats and found no statistical difference between the effect of OCT and CHX in dental plaque and dental carries formation.…”

Section: Discussionmentioning

confidence: 99%

“…Recently a new bispyridine antimicrobial compound -0.1% octenidine dihydrochloride (OCT)has been developed as a potential antimicrobial/ antiplaque agent for use in mouthwash formulations. [16][17][18][19] It has been shown to be a mucous membrane antiseptic and is also used in severe burns and for wound healing. OCT has also been suggested as an endodontic irrigant based on its antimicrobial effects and lower cytotoxicity.…”

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confidence: 99%

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Effects of Antiseptics on Pulpal Healing under Calcium Hydroxide Pulp Capping: A Pilot Study

et al. 2011

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Objectives:The objective of this pilot study was to evaluate the effects of three different antiseptic materials on healing processes of direct pulp therapies with Ca(OH)2 histopathologically.Methods:Twenty-eight upper and lower first molar teeth from 7 male Wistar rats were used in this study. Four cavities were prepared in each rat in four quadrants, and each quadrant represented different experimental groups. In Group I: 0.5% sodium hypochlorite (NaOCl); in Group II: 2% chlorhexidine digluconate (CHX); in Group III: 0.1% octenidine dihydrochloride (OCT); and in Group IV 0.9% sterile saline was applied to the exposure site with a sterile cotton pellet for 3 minutes. After hemorrhage control, the pulps were capped with hard setting Ca(OH)2 and, finally, restored with IRM. The animals were euthanized at 21 days post-operatively. After sacrificing, routine histological procedures were performed and evaluated statistically with non-parametric Kruskal-Wallis test among the groups and two-by-two comparisons by using the Mann-Whitney U test for inflammatory response and tissue organization scores at the confidence interval of 95%.Results:There were significant differences in inflammatory response and tissue organization scores between the groups (P<.05). Statistical evaluation of inflammatory response showed that Group IV was significantly different from Groups I, II and III separately with a higher inflammatory cell response (P<.05) whereas no significant differences were detected between the other groups in two-by-two comparisons (P>.05). Healthy coronal and radicular pulp tissue organization scores indicated that the Group I has better pulp tissue organization than Group IV and this was significantly different (P<.05) whereas no significant differences were observed between the other groups separately (P>.05).Conclusions:The antiseptic materials used in this study created an environment that, rather than saline solution, may affect clinical and histological success in a positive way.

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Muramyl dipeptide (MDP) analogues were prepared and utilized in the synthesis of new fluorescently labeled MDP derivatives for use as biologic probes. Thus, jVa-(jV-acetylmuramyl)-L-lysyl-D-isoglutamine (Lys-MDP, 4) and iVa-(jV-acetylmuramyl)-L-alanyl-D-isogutaminyl)-L-lysine [MTP,5] were synthesized and then reacted with 2-(fluoresceinylamino)-4,6-dichloro-s-triazine (DTAF, 2) to yield the fluorescent adducts, DTAF-Lys-MDP ( 6) and DTAF-MTP (7). The adjuvant activity of the fluorescent MDP derivatives was determined by the ability of the compounds to promote delayed skin test responses in guinea pigs immunized with ovalbumin (OA) and by evaluating the anti-OA activity of these guinea pigs.

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mentioning

confidence: 99%

Synthesis of fluorescent muramyl dipeptide congeners. 2

Hiebert

Kopp²,

Richerson³

et al. 1988

J. Med. Chem.

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Muramyl dipeptide (MDP) analogues were prepared and utilized in the synthesis of new fluorescently labeled MDP derivatives for use as biologic probes. Thus, N alpha-(N-acetylmuramyl)-L-lysyl-D-isoglutamine (Lys-MDP, 4) and N alpha-(N-acetylmuramyl)-L-alanyl-D-isoglutaminyl)-L-lysine [MTP, 5] were synthesized and then reacted with 2-(fluoresceinylamino)-4,6-dichloro-s-triazine (DTAF, 2) to yield the fluorescent adducts, DTAF-Lys-MDP (6) and DTAF-MTP (7). The adjuvant activity of the fluorescent MDP derivatives was determined by the ability of the compounds to promote delayed skin test responses in guinea pigs immunized with ovalbumin (OA) and by evaluating the anti-OA activity of these guinea pigs.

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The effect of daily treatments with an octenidine dentifrice formulation on gingival health in Cynomolgus monkeys

Cited by 4 publications

References 20 publications

The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis

The effect of a dentifrice containing zinc citrate and Triclosan on developing gingivitis

Effects of Antiseptics on Pulpal Healing under Calcium Hydroxide Pulp Capping: A Pilot Study

Synthesis of fluorescent muramyl dipeptide congeners. 2

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