OEIS is an extremely rare constellation of malformations, which includes omphalocele, exstrophy of cloaca, imperforate anus, and spinal defect. We report here autopsy findings in a case of OEIS complex, which apart from the major anomalies of the complex had bilateral club foot that is, congenital talipes equinovarus, right hydroureter, and body stalk anomaly. The umbilical cord was absent, and the umbilical vessels were embedded in an amniotic sheet, which connected the skin margin of the anterior body wall defect to the placenta, this feature being the hallmark of limb body wall complex (LBWC). This case further supports the view that OEIS and LBWC represent a continuous spectrum of abnormalities rather than separate conditions and may share a common etiology and pathogenetic mechanism as proposed by some authors.

Background and Objectives: Seroprevalence estimation of COVID-19 is quite necessary for controlling the transmission of SARS-CoV-2 infection. Seroprevalence rate in recovered COVID-19 patients help us to identify individual with anti-SARS-CoV-2 antibodies and its protective nature. The objective of present study was to evaluate seroprevalence of SARS-CoV-2 among potential convalescent plasma donors and analysis of their deferral reasons. Materials and Methods: A total 400 potential convalescent plasma donors were enrolled over five-month period for this prospective study. Inclusion criteria were lab confirmed COVID-19 recovered patients and 14 days of symptoms free period. All prospective plasmapheresis donors were tested for IgG SARS-CoV-2 antibody through chemiluminescent microparticle immunoassay, CBC, serum protein, blood grouping along with other required test for normal blood donation as per Drugs & Cosmetics Act. After pre donation testing and medical examination if donor was found to be ineligible for plasmapheresis was deferred. Seroprevalence rate was calculated by positive IgG antibody test results among the potential plasma donors. Results: Seroprevalence rate was 87% for IgG SARS-CoV-2 antibodies in prospective convalescent plasma donors (recovered COVID-19 patients). There was no significant difference in seroprevalence rate between different sub-groups with respect to gender, age, blood groups, Rh factor, mode of treatment, day of Ab testing and repeat plasma donation. Most common reason for their deferral was absent IgG SARS-CoV-2 antibodies (13%) followed by absenteeism of eligible screen donors (6.7%), low Hb (1.7%) and poor veins for plasmapheresis (1.7%). Till five-month study period none of the plasmapheresis develop symptoms of reinfection with COVID-19. Conclusion: 13% recovered patients did not develop IgG antibodies after SARS-CoV-2 infection. SARS-CoV-2 IgG antibodies persist for quite some time and are protective against reinfection. More long-term serology studies are needed to understand better antibody response kinetics and duration of persistence of IgG antibodies.

Tracheal agenesis (TA) is an extremely rare malformation. We report here autopsy findings in a case of TA with bronchoesophageal fistula of Floyd type III. The other malformations present included laryngeal atresia, Right lung hypolobulation, ventricular septal defect in membranous portion, bilateral cystic renal dysplasia, spleninculus, Meckel's diverticulum, and imperforate anus. The constellations of malformations present in our case have overlapping features with Vertebral anomalies, Anal atresia, Cardiovascular anomalies, Tracheo-esophageal fistula, Esophageal atresia, Renal anomalies, Limb anomalies and Tracheal atresia or laryngo tracheal atresia, Cardiac anomalies, Renal anomalies, Duodenal atresia association described previously in the literature.

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Background: Renal cell carcinoma (RCC) accounts for 80-85% of malignant kidney tumors. However incidence of RCC is less in Asian Countries including India and data available from Indian studies is scarce. Outcome of RCC depends on the morphological type and hence accurate classification is essential. Aims and Objectives: The objective of the present study was to assess the profile of patients of RCC in respect to age distribution, Sex distribution, laterality of the tumor, location within the kidney and Pathological tumor stage and compare our results with available literature from India and other countries. Material and Methods:The study is a retrospective study, which was conducted over a three and half year period from January 2016 to June 2019 at Goa Medical College, Bambolim Goa. A total of 60 cases of RCC diagnosed over this period were included in the study. Patient details were obtained from the Histopathology requisition forms from the records of Pathology department. The data was collected, analysed and compared with other similar studies. Histopathological examination of the specimens was conducted using standard processing technique and taking 5 micron sections and staining by Hematoxylin and Eosin technique. Results: A total of 60 cases of RCC were diagnosed over 3and 1 2 year period with Clear Cell Carcinoma 38(63.3%) cases being the commonest histopathological type. The tumor was more commonly seen in males with a M:F ratio of 3.6:1. The age ranged from 25 to 78 years with a median of 56.5 years which is decade earlier as compared to Western data. The tumor size(Pathological stage pT) in this study was lower with 24 cases(40%) being diagnosed in pTa stage and 22cases(36.7%) treated with nephron sparing surgery which is a much higher figure as compared to other Indian studies.