Graphene liquid cell electron microscopy (GLC-EM), a cutting-edge liquid-phase EM technique, has become a powerful tool to directly visualize wet biological samples and the microstructural dynamics of nanomaterials in liquids. GLC uses graphene sheets with a one carbon atom thickness as a viewing window and a liquid container. As a result, GLC facilitates atomic-scale observation while sustaining intact liquids inside an ultra-high-vacuum transmission electron microscopy chamber. Using GLC-EM, diverse scientific results have been recently reported in the material, colloidal, environmental, and life science fields. Here, the developments of GLC fabrications, such as first-generation veil-type cells, second-generation well-type cells, and third-generation liquid-flowing cells, are summarized. Moreover, recent GLC-EM studies on colloidal nanoparticles, battery electrodes, mineralization, and wet biological samples are also highlighted. Finally, the considerations and future opportunities associated with GLC-EM are discussed to offer broad understanding and insight on atomic-resolution imaging in liquid-state dynamics.

The recent advances in liquid‐phase transmission electron microscopy represent tremendous potential in many different fields and exciting new opportunities. However, achieving both high‐resolution imaging and operando capabilities remain a significant challenge. This work suggests a novel in situ imaging platform of liquid‐flowing graphene chip TEM (LFGC‐TEM) equipped with graphene viewing windows and a liquid exchange system. The LFGCs are robust under high‐pressure gradients and rapid liquid circulation in ranges covering the experimental conditions accessible with conventional thick SiNx chips. LFGC‐TEM provides atomic resolution for colloidal nanoparticles and molecular‐level information limits for unstained wet biomolecules and cells that are comparable to the resolutions achievable with solid‐phase and cryogenic TEM, respectively. This imaging platform can provide an opportunity for live imaging of biological phenomena that is not yet achieved using any current methods.

The design of nanostructured materials for efficient bifunctional electrocatalysts has gained tremendous attention, yet developing a fast and effective synthesis strategy remains a challenge. Here, we present a fast and...

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