Background:Vaginal discharge is one of the most common problems faced by women. It may be physiological or pathological. Most of the time it caused by bacteria, fungi or parasites and many times these infections are sexually transmitted. Thus it is important to treat vaginal discharge as syndrome. Syndromic management is an inexpensive and effective method to treat vaginal discharge and no preliminary laboratory test are required. We have studied 300 patients attending OPD with complain of vaginal discharge to access the efficiency, acceptability and tolerance of one day combination kit therapy (azithromycin 1 g, fluconazole 150 mg and Secnidazole 2 g). Methods: Three hundred women were selected randomly with the complaint of vaginal discharge. They were examined thoroughly and advised to take one day kit therapy. Their partners were also advised to take same therapy. They were called after two weeks to know about their symptoms and for examination. Results: Sixty percent women had excellent response for vaginal discharge, 75% women had excellent response for urinary symptoms and 77.3% women had excellent response for pruritus vulvae. Conclusions: The combination kit therapy in vaginal discharge allows a simple and fast assured therapy, with high cure rate for vaginal discharge.