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This work evaluates permeation of twelve model pharmaceutical compounds through a chemically modified form of poly(dimethylsiloxane) (PDMS), whereby the polymer surface had undergone silanisation. Standard polymer membrane has been widely used as a simplified skin model to investigate transdermal permeation yet does not fully mimic human skin. The surface chemistry of modified polymer was investigated such as the ability to bind to drugs, hydrophobicity and pore size using optical microscopy, the Brunauer-Emmett-Teller (BET) technique and Fourier-transform Infrared Spectroscopy (FTIR), followed by permeation analysis with UV spectroscopy. For eleven of the twelve compounds an appreciable increase in the extent of permeation was observed after six hours when using the silanised polymer compared with the standard PDMS. Furthermore, a correlation was found between the degree of permeation increase and hydrophobicity (logP) of the drug (R 2 = 0.90). These findings indicate that permeation can be controlled by modifying the membrane surface, although the hydrophobicity of the permeant also plays a vital role in the extent of permeation observed. This concept study presents a potential alternative membrane for pharmaceutical transdermal analysis, providing many benefits over existing options.

A series of four mixed ligand complexes synthesized by reacting benzoylacetone and salicylaldehyde with different metal chlorides in ethanolic medium, were tested for their antimicrobial studies and indicated that the compounds are active against microorganisms used (Escherichia coli, Staphylococcus aureus, and Candida albicans) when compared with the activity of the reference or standard drugs (Erythromycin and Suptrin).Keywords: Antimicrobial, Synthesis, Ligands, Complexes

A series of four mixed ligand complexes were synthesized by reacting benzoylacetone and salicylaldehyde with different metal chlorides in ethanolic medium. The complexes have been characterized by molar conductance measurements and spectral techniques such as IR and Uv-visible electronic spectra. Decomposition temperature was also determined. The results indicated that the compounds have bands at 400-500cm-1, with very sharp melting points. This proved the formation of metal-oxygen bond, purity and high thermal stability of the compounds that could lead to a high antimicrobial activity.Keywords: Adduct Synthesis, Ligands, and Complexes