Background: In adults, seizure disorder is a one of major health concern in terms of burden of disease, nature of illness,and its impact on individual, family, and community. The present study was undertaken to assess clinical types, pathogenesis and clinical profile of seizures in adult and to study clinical correlation of seizures with EEG and Neuro imaging and hospital outcome after antiepileptic treatment. Methods: Total 130 cases of age >12 years to till age presenting with new onset seizures were included in the study,during the period of one year from September 2019 to -August 2020. A detailed history was taken, clinical examination, laboratory investigation and EEG, CT/ MRI were done. Results: The mean age of cases was 27.8 ± 3.6 years withmales’ predominance (82; 63.1%).Convulsion was the mostcommon presenting complaint (96 (73.8%) and GTCS was the most common type of seizure observed in 43 (33.1%) cases. The most common predisposing factor was stroke, found in 31 (23.8%) cases. On EEG report the most common pattern found was multifocal spike (42; 32.3%) while on MRI calcified neurocystecercosis was found in 4 cases (3.1%). Scar epilepsy was most common (42; 32.3%) followed by stroke infarct (21; 16.2%). The most common drug used for management of the cases was valproate (72; 55.4%) followed by phenytoin (58; 44.6%). Conclusion: Identification and awareness about the etiological factors and seizure type help in better management of adultpatients. Primary care physicians play a pivotal role in identifying patients with adult onset seizures and should encourage these patients to undergo neuroimaging so as to arrive at an appropriate etiological diagnosis.

Objective: Metabolic syndrome (MetS) and subclinical hypothyroidism (SCH) both are known to have adverse cardiovascular outcomes. Available studies have shown variable results on the association of SCH with MetS as well as individual components of MetS. We aimed to study the association of SCH with MetS and its individual components of MetS. Material and Methods: This cross-sectional study was carried out in individuals volunteered for health checkup at Department of Medicine, Darbhanga Medical College and Hospital, Laheriasarai, Bihar. About 60 cases with MetS and 120 controls without having MetS were recruited. Demographic data such as history of diabetes mellitus, hypertension, dyslipidemia, blood pressure (BP), waist circumference and serum T3, serum T4, thyroid stimulating hormone, fasting blood sugar, fasting lipid profile, and hemoglobin A1c were collected and statistically analyzed. Statistical analysis was done by using SPSS sav software packages. Chi-square test was used for the comparison of qualitative data. Results: SCH was present in 52 (28.9%) among 180 study participants. SCH was present in 35 (58.33%) participants having MetS and in 17 (14.16%) of controls. There was a strong association between SCH and MetS (p<0.001). Significant association of SCH with diastolic BP (p=0.017) and with central obesity (p=0.004) was observed but not with high-density lipoprotein, triglyceride, hyperglycemia, systolic BP, total cholesterol, and low-density lipoprotein. Conclusion: We observed a strong association of SCH with MetS. We also observed significant association of SCH with diastolic BP and with obesity. The finding of this study indicates the need to screen individuals with MetS for SCH.