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Dyspareunia, a painful sexual disorder can be correlated to Paripluta yonivyapath (disorders of the genital tract) as per Ayurveda classics, which comes under the category of Female sexual dysfunction, the less explored clinical field in Ayurveda. Bala, Sida cordifolia Linn is the single drug that is directly indicated in this disease condition. This is the era in which the whole medical world is running behind in standardizing Evidence-based medicine (EBM) in clinical application. Network pharmacology, a branch of science that combines Network biology and polypharmacology, which predicts the mode of action of therapeutic drugs on both the interactome and the diseasome level. Here is an attempt to put forth the therapeutic efficacy of Bala in Dyspareunia through network pharmacology and bonding energy was demonstrated by molecular docking. Methods: Phytochemicals of Bala were collected from the IMPPAT database and related research articles. The disease targets were obtained from databases namely the Therapeutic target database, ChEMBL, Human protein atlas, and DisGeNet. The therapeutic efficacy of these gene targets in dyspareunia is confirmed and the conclusion is obtained from the network pharmacological ligand-target interaction methodology. The ligands and targets were retrieved from the PubChem, Protein Data Bank and docked using PyRx software. Results and Conclusion: The current study identified important Phyto-constituents like Resin Acid, Malvalic Acid, 5,7-Dihydroxy-3-Isoprenyl Flavones, Peganine, Β-Phenethylamine, Ψ-( Pseudo) -Ephedrine, Coronaric Acid, Potassium Nitrate, Phenethylamine, Ephedrine, Choline which were highly modulating CYP19A1, ESR2, MAPK1, AR, MAPK3, ESR1, CYP19A1, PGR proteins related with Dyspareunia.

A study was undertaken to evaluate antihyperlipidemic activity of ethanolic extract of leaves of Mentha arvensis in Triton and high cholesterol diet induced hyperlipidemic male albino Wstar rats. Acute hyperlipidemia was induced by administration of Triton WR-1339 (100 mg / kg i.v.) to the male albino Wstar rats. In chronic models; the animals were fed with high cholesterol diet for a period of 10 days. EEMA leaves at a dose of 200 and 400 mg/kg of body weight were administered at a single dose per day to the hyperlipidemic induced rats for a period of 14 days. In hyperlipidemic rats there is significant increase in TC, TG, LDL, VLDL level and significant decrease in HDL level, but after post treatment with EEMA, there was a significant decrease in TC, TG, LDL, VLDL and increase in HDL level. Post treatment with EEMA leaves lowered levels of total protein and triglycerides.

The purpose of this study was to assess the impact of hydroalcoholic extract of Garcinia indica fruit on salt-induced cardiac remodeling in Sprague Dawley rats. Animals were fed with feed consisting of extra salt i.e. 2 %, 4 %, and 6 % w/w for 1,2,3 weeks respectively and 8 % w/w from 4th to 6th week; water was supplemented throughout the study with normal saline of 0.9% w/V. ECG was recorded weekly for assessing modifications in the heart function. Animals were sacrificed to obtain blood samples at the end of the study, which were centrifuged to obtain the serum to estimate various biochemical parameters including antioxidant biomarkers in the heart. G. indica treatment at a dosage of 200, 400, and 800mg/ kg showed significantly reduced dose-dependent in heart rate, QRS complex, RR-interval, and CK-MB. It also showed a significant increase in antioxidant biomarkers viz. compared with untreated group SOD, GSH, and CAT. The experimental result underscored G.indica's antioxidant and cardioprotective effects on cardiac remodeling.

The present study is aimed to evaluate the effect of ylang ylang essential oil in alcohol induced hepatotoxicity in rats. Alcohol was used as an inducing agent and Silymarin as a standard molecule. Body weight was measured at a 3 days interval till the twenty first day and at the end of the study, serum AST, ALT, TP, TC, TG, and TB biomarkers were estimated. Further, the liver tissue was evaluated for antioxidant enzymes namely CAT, LPO, SOD and GSH level. Liver weight and histopathology was accessed at the end. Phytocompounds were shortlisted from literature and curated databases. Probable targets of each compound were identified using the SwissTargetPrediction web server. Probable mechanisms of phytocompounds against Alcohol induced hepatotoxicity were analyzed by the STRING and KEGG pathway database. The network between compounds, targets, and pathways was generated via Cytoscape ver. 3.6.1. Docking was performed by AutoDock vina using PyRx0.8v. YYEO group showed increased BW compared to alcohol group and also reversed the increased serum AST, ALT, TP, TC, TG, and TB biomarkers and also increased the level of antioxidant enzymes compared to alcohol induced group. YYEO 400 mg/kg exhibited normal liver weight and histology compared to alcohol. Enrichment and network analysis identified YYEO 63 compounds as beneficial modulators of protein molecules associated with hepatotoxicity via modulating Toll-like receptor, Adipocytokine, TNF, Sphingolipid, FoxO, AMPK, Relaxin, MAPK, NF-kappa B, HIF-1, Fc epsilon RI, IL-17, VEGF, T cell receptor, NOD-like receptor, mTOR, PI3K- Akt signaling pathway, etc. Canangaterpene 1 was identified as a potent inhibitor of aldose reductase. Graphical abstract