Background: Data regarding the clinical profile of end-stage renal disease (ESRD) and dialysis in Mid western Nepal are scarce and knowledge about the spectrum of renal disease is very limited. This study was about the clinical profile of patients with ESRD in a tertiary hospital of Lumbini province of Nepal. Materials and Methods: This was a retrospective, observational study carried out in a dialysis unit in a tertiary hospital. Forty patients who were on maintenance haemodialysis on regular a basis in the hospital for at least 3 months were selected for the study. Patients demographic, clinical data and laboratory parameters were recorded in preformed performa. Data were entered into Statistical Package for the Social Sciences 21 and descriptive analysis was done. Results: Most of the patients were in the age group 20 to 60 years 33(82.5%). Male: female ratio of 1.6:1. Most common cause for end stage renal disease was hypertension followed by diabetes. Anaemia, hypocalcaemia and hyponatremia were found to be the common complications associated with the patients. Conclusion: Early diagnosis and treatment of hypertension and diabetes may be the key to decrease the incidence of chronic kidney disease patients and also halt the progression to End stage renal disease. Key words: Chronic kidney disease, haemodialysis, end stage renal disease