CuO nanoparticles have been studied for C-N, C-O, and C-S bond formations via cross-coupling reactions of nitrogen, oxygen, and sulfur nucleophiles with aryl halides. Amides, amines, imidazoles, phenols, alcohols and thiols undergo reactions with aryl iodides in the presence of a base such as KOH, Cs(2)CO(3), and K(2)CO(3) at moderate temperature. The procedure is simple, general, ligand-free, and efficient to afford the cross-coupled products in high yield.

The Rh(III)-catalyzed C8-allylation of quinoline N-oxides has been accomplished using vinylcyclopropanes as an allyl source with excellent diastereoselectivity at room temperature. The C-H/C-C activation, substrate scope and natural product mutation...

Substitution reactions O 0040CuO Nanoparticles Catalyzed C-N, C-O, and C-S Cross-Coupling Reactions: Scope and Mechanism. -The reactions allow simple, general, and efficient access to a wide range of aromatic amines, phenol ethers, and thioethers. -(JAMMI, S.; SAKTHIVEL, S.; ROUT, L.; MUKHERJEE, T.; MANDAL, S.; MITRA, R.; SAHA, P.; PUNNIYAMURTHY*, T.; J.

Rh-catalyzed weak and traceless directing-group-assisted cascade C− H activation and annulation of sulfoxonium ylides with vinyl cyclopropanes as a coupling partner have been accomplished to furnish functionalized cyclopropanefused tetralones at moderate temperature. The C−C bond formation, cyclopropanation, functional group tolerance, late-stage diversifications of drug molecules, and scale-up are the important practical features.

C8-Substituted quinoline (QN) and 1,2,3,4-tetrahydroquinoline (THQ) scaffolds are featured largely in a plethora of bio-active compounds and natural products. Appreciable efforts have thus been made towards the development of elegant techniques to functionalize the C8-H bond of QNs and THQs. Transition-metal-catalyzed chelation assisted C-H activation strategy has emerged as an effective synthetic tool among existing methods. This review focuses on the recent advances in the transition-metal-catalyzed directed carbon-carbon bond forming reactions for the C8-H functionalization of QNs and THQs (till February 2023). The discussion has been summarized categorically on the type of reactions.