Inertial measurement units (IMUs) have shown promising outcomes for estimating gait event detection (GED) and ground reaction force (GRF). This study aims to determine the best sensor location for GED and GRF prediction in gait using data from IMUs for healthy and medial knee osteoarthritis (MKOA) individuals. In this study, 27 healthy and 18 MKOA individuals participated. Participants walked at different speeds on an instrumented treadmill. Five synchronized IMUs (Physilog®, 200 Hz) were placed on the lower limb (top of the shoe, heel, above medial malleolus, middle and front of tibia, and on medial of shank close to knee joint). To predict GRF and GED, an artificial neural network known as reservoir computing was trained using combinations of acceleration signals retrieved from each IMU. For GRF prediction, the best sensor location was top of the shoe for 72.2% and 41.7% of individuals in the healthy and MKOA populations, respectively, based on the minimum value of the mean absolute error (MAE). For GED, the minimum MAE value for both groups was for middle and front of tibia, then top of the shoe. This study demonstrates that top of the shoe is the best sensor location for GED and GRF prediction.

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Altered tibiofemoral contact forces represent a risk factor for osteoarthritis onset and progression, making optimization of the knee force distribution a target of treatment strategies. Musculoskeletal model-based simulations are a state-of-the-art method to estimate joint contact forces, but they typically require laboratory-based input and skilled operators. To overcome these limitations, ambulatory methods, relying on inertial measurement units, have been proposed to estimated ground reaction forces and, consequently, knee contact forces out-of-the-lab. This study proposes the use of a full inertial-capture-based musculoskeletal modelling workflow with an underlying probabilistic principal component analysis model trained on 1787 gait cycles in patients with knee osteoarthritis. As validation, five patients with knee osteoarthritis were instrumented with 17 inertial measurement units and 76 opto-reflective markers. Participants performed multiple overground walking trials while motion and inertial capture methods were synchronously recorded. Moderate to strong correlations were found for the inertial capture-based knee contact forces compared to motion capture with root mean square error between 0.15 and 0.40 of body weight. The results show that our workflow can inform and potentially assist clinical practitioners to monitor knee joint loading in physical therapy sessions and eventually assess long-term therapeutic effects in a clinical context.

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