Objective To analyse the mortality rate trend due to coronary heart disease (CHD) and stroke in the adult population in Brazil. Methods From 2000 to 2018, a time trend study with joinpoint regression was conducted among Brazilian men and women aged 35 years and over. Age-adjusted and age, sex specific CHD and stroke trend rate mortality were measured. Results Crude mortality rates from CHD decreased in both sexes and in all age groups, except for males over 85 years old with an increase of 1.78%. The most accentuated declining occurred for age range 35 to 44 years for both men (52.1%) and women (53.2%) due to stroke and in men (33%) due to CHD, and among women (32%) aged 65 to 74 years due to CHD. Age-adjusted mortality rates for CHD and stroke decreased in both sexes, in the period from 2000 to 2018. The average annual rate for CHD went from 97.09 during 2000–2008 to 78.75 during 2016–2018, whereas the highest percentage of change was observed during 2008 to 2013 (APC -2.5%; 95% CI). The average annual rate for stroke decreased from 104.96 to 69.93, between 2000–2008 and 2016–2018, and the highest percentage of change occurred during the periods from 2008 to 2013 and 2016 to 2018 (APC 4.7%; 95% CI). Conclusion The downward trend CHD and stroke mortality rates is continuing. Policy intervention directed to strengthen care provision and improve population diets and lifestyles might explain the continued progress, but there is no room for complacency.

A nationally generalisable cohort (n=5770, 7-12-month-old children) was used to determine prevalence of non-timely (early/late) introduction of complementary food and core food groups and associations with maternal sociodemographic and health behaviours in New Zealand (NZ). Variables describing maternal characteristics and infant food introduction were sourced, respectively, from interviews completed antenatally and during late infancy. The NZ Infant Feeding Guidelines were used to define early (<4 months) and late (≥7 months) food introduction. Associations were examined using multivariable multinomial regression, presented as adjusted relative risk ratios (RRR) and 95% confidence intervals (CI). Complementary food introduction was early for 40.2% and late for 3.2%. The prevalence’s of early food group introduction were: fruit/vegetables (23.8%), breads/cereals (36.3%), iron-rich foods (34.1%); and of late were: meat/meat alternatives (45.9%), dairy products (46.2%), fruits/vegetables (9.9%). Compared to infants with timely food introduction, risk of early food introduction was increased for infants: breastfed <6 months (RRR=2.52; 95%CI 2.19-2.90); whose mothers were <30 years old (1.69; 1.46-1.94), had a diploma/trade certificate versus tertiary education (1.39; 1.14-1.70), of Māori versus European ethnicity (1.40; 1.12-1.75), or smoked during pregnancy (1.88; 1.44-2.46). Risk of late food introduction decreased for infants breastfed <6 months (0.47; 0-2.7-0.80) and increased for infants whose mothers had secondary versus tertiary education (2.04; 1.16-3.60), were of Asian versus European ethnicity (2.22; 1.35–3.63), or did not attend childbirth preparation classes (2.23; 1.24–4.01). Non-timely food introduction, specifically early food introduction, is prevalent in NZ. Interventions to improve food introduction timeliness should be ethnic-specific and support longer breastfeeding.

Background: Coronary Artery Calcification (CAC) is considered an important cardiovascular risk factor. There is evidence that CAC is associated with an increased risk of atherosclerosis, coronary events and cardiovascular mortality. Inflammation is one of the factors associated with CAC and despite the interest in antioxidant compounds that can prevent CAC, its association with antioxidants remains unclear. Objective: This study aimed to systematically review the association between vitamins and minerals with antioxidant effects and CAC in adults and older adults. Methods: We conducted a systematic review using PubMed for articles published until October 2018. We included studies conducted in subjects aged 18 years and older with no previous cardiovascular disease. Studies involving animal or in vitro experiments and the ones that did not use reference methods to assess the CAC, dietary intake or serum levels of vitamin or mineral were excluded. Results: The search yielded 390 articles. After removal of duplicates, articles not related to the review, review articles, editorials, hypothesis articles and application of the inclusion and exclusion criteria, 9 articles remained. The results of the studies included in this systematic review suggest that magnesium is inversely associated with CAC and results on the association between CAC and vitamin E have been conflicting. Conclusion: Additional prospective studies are needed to elucidate the role of these micronutrients on CAC.

INTRODUCTION:The first 1000 days of life, from conception to two years age, are critical to the infant's health. Non-timely introduction of foods (early or late) is associated with infections of the gastrointestinal and respiratory tracts, iron deficiency, obesity and food allergies. New Zealand lacks nationally generalizable information on timing of food introduction and the sociodemographic determinants of non-timely introduction of complementary feeding. OBJECTIVES: i) To investigate the age of introduction of complementary feeding and of recommended food groups within the Growing Up in New Zealand -GUiNZ cohort and; ii) To examine the maternal and infant factors associated with early and late introduction of these foods. METHODS: The GUiNZ study is a New Zealand birth cohort which follows nearly 7000 children. Maternal sociodemographic and lifestyle information was collected in the antenatal interview and infant's information was prevenient from the six-week, nine and 31-month interviews. It was considered as complementary food any food item other than breast milk or infant formula that was introduced to babies. Prevalence of early, timely and late age of food introduction were evaluated according to the recommendations of the New Zealand Ministry of Health and the World Health Organization (overall and according to sex and breastfeeding duration). Associations between maternal and infant factors with early and late introduction of foods were examined using multivariate multinomial regressions. Multivariate Poisson regressions with robust variance were performed to examine maternal and infant factors associated with the introduction of snacks and sugary drinks up until the 9-month interview (yes/no). RESULTS: Among the 5770 children included in this study, complementary feeding was introduced early (<4 th month) to 40% and late (>7 th month) to 3,2%. The groups "fruits and vegetables", "breads and cereals" and "iron rich foods" were early introduced to 24%, 36% and 34% of the infants, respectively. "Meat and alternatives", which includes foods rich in protein from animal and vegetable sources, and products from the "dairy" group were introduced late to 46% of the infants. The prevalence of introduction of 'snacks' and 'sugary drinks' by the time of the 9month interview were 52% and 38%, respectively. Mothers who breastfed for less than 6 months and/or never breastfed, who were younger than 30 years old, who were from Maori ethnicity, who had high pre-pregnancy BMI, who had unplanned pregnancy, who did not attend to maternity preparation classes and who smoked before and/or during pregnancy were more likely to introduce their babies foods earlier (in relation to mothers of babies who were timely introduced). Mothers who breastfed for less than 6 months, who did not attend to maternity preparation classes, who were from Maori, Pacific or Asian ethnicities and who had lower level of formal education were more likely to introduce their babies foods late (in relation to mothers of babies who were timely introduced...