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The judgment of thermal comfort is a cognitive process which is influenced by physical, psychological and other factors. Prior studies have shown that occupants, who are generally satisfied with many non-thermal conditions of indoor environmental quality, are more likely to be satisfied with thermal conditions as well. This paper presents a novel approach that considers the effect of non-thermal building environmental design conditions, such as indoor air quality and noise levels, on perceived thermal comfort in open-plan offices. The methodology involves the use of Bayesian inference to relate the occupant’s thermal dissatisfaction in a building not only to thermal conditions and occupant metabolic factors (i.e., parameters of the original Fanger model), but also to measurable non-thermal metrics of indoor environmental quality. A Bayesian logistic regression approach is presented in this paper. The experimental context regards a prior indoor environmental quality measurement and evaluation study of 779 occupants of open-plan offices throughout Canada and the US. We present revised PMV-PPD curves for real-world offices that take into account both thermal and wellbeing IEQ parameters. The Bayesian inference analysis reveals that the occupant’s thermal dissatisfaction is influenced by many non-thermal IEQ conditions, such as indoor CO2 concentrations and the satisfaction with the office lighting intensity.