The coi1 mutation defines an Arabidopsis gene required for response to jasmonates, which regulate defense against insects and pathogens, wound healing, and pollen fertility. The wild-type allele, COI1, was mapped to a 90-kilobase genomic fragment and located by complementation of coi1-1 mutants. The predicted amino acid sequence of the COI1 protein contains 16 leucine-rich repeats and an F-box motif. It has similarity to the F-box proteins Arabidopsis TIR1, human Skp2, and yeast Grr1, which appear to function by targeting repressor proteins for removal by ubiquitination.

Aim The study aimed to investigate the effectiveness of a web‐based therapy programme, ‘Move it to improve it’ (Mitii™), in children with unilateral cerebral palsy (UCP) on occupational performance, upper limb function, and visual perception. Method Participants (n=102) were matched in pairs and randomized to intervention (Mitii for 20wks; 26 males, mean age 11y 8mo [2y 4mo], Manual Ability Classification System level I=11, II=39, III=1) or control (standard care; 25 males, mean age 11y 10mo [2y 5mo], Manual Ability Classification System level I=13, II=37). Outcomes were the Assessment of Motor and Process Skills (AMPS), Assisting Hand Assessment, Jebsen–Taylor Test of Hand Function (JTTHF), Melbourne Assessment of Unilateral Upper Limb Function (MUUL), Canadian Occupational Performance Measure (COPM), and Test of Visual Perceptual Skills (TVPS‐3). Results Participants completed on average 32.4 hours of Mitii (range 3.7–74.7h). The Mitii group demonstrated significantly greater post‐intervention scores than the comparison group on the AMPS, JTTHF dominant upper limb, COPM, and TVPS‐3. The differences between groups were not clinically significant. There were no differences between groups on measures of impaired upper limb function. Interpretation Mitii delivers individualized, web‐based therapy at home and has potential to increase therapy dose. Mitii can be considered as an option to enhance occupational performance and visual perception for children with UCP.

AIM This study aimed to systematically review the psychometric properties and clinical utility of measures of activities of daily living (ADL) for children with cerebral palsy (CP) aged 5 to 18 years.METHOD Five electronic databases were searched to identify available ADL measures with published psychometric data for school-aged children with CP. Measures were included if at least 60% of the items addressed ADL in the full assessment or in an independent domain. A modified CanChild Outcome Rating Form was used to report the validity, reliability, responsiveness, and clinical utility of the measures.RESULTS Twenty-six measures were identified and eight met inclusion criteria. The Pediatric Evaluation of Disability Inventory (PEDI) had the strongest psychometric properties but was limited by its age range. The Assessment of Motor and Process Skills (AMPS) was the most comprehensive evaluation of underlying motor and cognitive abilities yet further psychometric testing is required for children with CP.INTERPRETATION The PEDI should be used to measure ADL capability in elementary school aged children. The AMPS is the best measure to evaluate ADL performance or capacity and is suitable for all ages. Future research should examine the reliability of the AMPS to determine its stability in children and adolescents with CP.The focus of assessment and treatment of children with cerebral palsy (CP) has changed in response to the introduction of the International Classification of Functioning, Disability and Health (ICF). 1 The ICF has evolved since its inception and today comprises four components: (1) body structures; (2) body functions; (3) activities and participation; and (4) environmental factors.2 The conceptualisation of disability in the ICF highlights its biopsychosocial nature and emphasises the need to support individuals to achieve optimal capacity and participation in all aspects of life.3 Broadening intervention goals to address all areas of functioning necessitates the identification of outcome measures that capture each aspect. 4 Cerebral palsy is defined as 'a group of permanent disorders of the development of movement and posture, causing activity limitations, that are attributed to non-progressive disturbances which occurred in the developing fetal or infant brain '. 5 Activities of daily living (ADL) are tasks that are fundamental to supporting participation across school, home and community environments. ADL are conceptualised in the 'Activities and Participation' domain of the ICF and defined as life tasks required for self-care and self-maintenance such as grooming, bathing, eating, and doing chores. 6 These tasks are classified as either (1) personal ADL tasks, which are oriented towards self-care (e.g. grooming, bathing); or (2) instrumental ADL tasks, which are oriented towards sustaining independence and require a higher level of physical and cognitive competency than personal ADL (e.g. preparing meals, taking care of pets). 7 Personal ADL are more commonly performed by younger children, whi...