Introduction: Internet addiction is currently considered a worldwide problem, with a possible impact on mental health. Young adults are recognized to be at high risk of developing Internet gaming disorder (IGD). According to a recent clinical model, young adults with IGD may endorse a distinct set of maladaptive beliefs that underlie persistent and excessive engagement in Internet gaming activities. The objective of this study was to examine the incidence of problematic gaming beliefs and psychological distress in a sample of “Indian Young Adults” with and without IGD. Methods: The research is descriptive in nature, conducted during the month of April 2022–May 2022 on a sample of 306 young adults (185 males and 121 females) recruited from multiple universities. A Google form survey that included validated measures of IGDs, Internet gaming cognition, and psychological distress were distributed on various online platforms for collecting the data. Results: According to the findings, young adults with IGD report significantly higher maladaptive gaming beliefs (t = 16.199, P < 0.001) and psychological distress (depression - t = 12.11. P = < 0.001 and anxiety/stress - t = 10.95, P = < 0.001) than young adults without IGD. The size of observed effects was large for cognition (Cohen's d = 2.14), depression (Cohen's d = 2.14), and anxiety/stress (Cohen's d = 1.96). The sample also reported strong correlation between IGD symptoms and gaming cognitions (P = <0.001). Further hierarchical regression analysis revealed depression variables as a significant predictors in the final model (β = 0.212, P = 0.002, confidence interval [CI] = 0.219–0.944) and overvaluation (β = 0.196, P = 0.020, CI = 0.048–0.545), maladaptive rules (β = 0.334, P = 0.003, CI = 0.117–0.551), and gaming social acceptance (β = 0.272, P = 0.001, CI = 0.190–0.693) as the three strongest cognition predictors of IGD symptoms. Conclusion: These findings indicate that young adults with IGD have distinct problematic thoughts about gaming and highlight the importance of addressing these cognitions in therapeutic interventions for the disorder.

One does not need to look far to find plenty of evidences of the influence of education on many important aspects of people’s lives.  So, if ‘happiness’ is understood in the robust eudaemonist sense of key for perfect living, then education evidently has an enormous impact. Education has become one of the clearest indicators of life outcomes such as employment, income and social status, and is a strong predictor of attitudes, wellbeing, good Quality of Life etc. Following Objectives were formed for the study: (i) To Assess and Compare Quality of Life of educated and uneducated Muslim Housewives. (ii) To assess and compare Well-Being of educated and uneducated Muslim housewife. 100 educated Muslim Housewives and 100 uneducated Muslim housewives were taken from District Aligarh. Snow Ball sampling technique was used for gathering the data. WHOQOL-BREF was used to assess Quality of life and Well- Being Scale was used to assess various well-being dimensions in both the groups. Significant Difference was found between various dimensions of quality of life and well-being of educated and non educated Muslim women of Aligarh district.

Objective To highlight the reasons of culture failure in bone marrow aspirate samples sent for Cytogenetic analysis and to identify the associated parameters causing this impact. Methodology This is a retrospective cross-sectional study conducted in the Clinical and Molecular Cytogenetics Laboratory of NIBD Hospital, Karachi, Pakistan. The rates of culture failure are assessed from the year 2017–2020 along with their reasons. Bone Marrow aspirate samples of patients with hematological malignancies were cultured for chromosomal analysis, both at the time of diagnosis or relapse. Statistical analysis was performed using SPSS version 25. Results A total of 1061 bone marrow aspirate samples were assessed for cytogenetic culture failures from the duration of 2017 to 2020. Ratio of males was predominantly higher i.e. 62.7% than female 37.3% with Mean ± SD age was 36.78 ± 18.94. Frequency of culture failure in the year 2020 was relatively high 20% as compared to the preceding years i.e. 8% in 2017, 6% in 2018, 7% in 2019. However, the patients were diagnosed with the following hematological malignancies; ALL 23%, CML 17.1%, AML 16.5% and AA 12.5%. Among the reasons of culture failure, cytogenetic analysis of patients with on-going chemo resulted in significant culture failures with p-value < 0.001 and the hematological malignancy, Acute Promyelocytic Leukemia, significantly impacted the growth of bone marrow aspirate cultures, with p-value < 0.001. Conclusion Significant findings were associated with causative factors of culture failure including on-going treatment and sample issues of clotted bone marrow as well as with the clinical diagnosis. These evaluations facilitated in overcoming the rise in culture failures. As per our knowledge, no such data, discussing the effects of various parameters such as sample quality, diagnosis, effects of treatment etc., has been documented previously.

Background: After cardiovascular problems, cancer is the 2nd biggest cause of mortality globally. Globally, breast cancer is recognized as the second most prevalent cancer in general, the most prevalent cancer in women, and the 5th major cause of cancer-related death. Objectives: To study the Morphologic Spectrum of Breast Carcinoma and correlation of hormone receptors and HER2/neu status with clinic-pathologic parameters Methods: A total of 97 consecutive cases of modified radical mastectomy were evaluated in the department of histopathology, Rehman Medical Institute Peshawar from February 2019 to December 2020. Expression of PR, ER and Her2/neu were scored similar to College of American Pathologist’s (CAP) guidelines. The analysis of data was done by using SPSS version. Results: Mean age of presentation was 49.6 years. The most prevalent histological subtype was invasive carcinoma of no particular type (72.2%). Grade II tumors were most frequent (43.3%). Lymphovascular and perineural invasion were present in 53.6% and 40.2% of cases respectively. Pathologic stage pT2 was most frequent (56.7%). Macrometastasis was noted in 61.8% of cases. ER and PR showed positivity in 59.8% and 51.5% of cases and Her2/neu was over expressed in 30.9% of cases. ER positivity inversely correlated with Her2/neu but directly with tumor size. Strong association was found between ER/PR positivity and HER2/neu with histologic grade. Conclusion: Our study showed a diverse spectrum of special type carcinomas, none of which showed HER2/neu over expression. Majority of our patients belong to a younger age group and presented with advanced disease. Triple negative breast cancer (TNBC) was commonest in our population after luminal A. HER2/neu overexpression was limited to grade 2 and 3 of invasive ductal carcinoma Keywords: Morphologic Spectrum; Breast Carcinoma; Hormone receptors