During the final growth phase of giant planets, accretion is thought to be controlled by a surrounding circumplanetary disk. Current astrophysical accretion disk models rely on hydromagnetic turbulence or gravitoturbulence as the source of effective viscosity within the disk. However, the magnetically-coupled accreting region in these models is so limited that the disk may not support inflow at all radii, or at the required rate.Here, we examine the conditions needed for self-consistent accretion, in which the disk is susceptible to accretion driven by magnetic fields or gravitational instability. We model the disk as a Shakura-Sunyaev α disk and calculate the level of ionisation, the strength of coupling between the field and disk using Ohmic, Hall and Ambipolar diffusevities for both an MRI and vertical field, and the strength of gravitational instability.We find that the standard constant-α disk is only coupled to the field by thermal ionisation within 30 R J with strong magnetic diffusivity prohibiting accretion through the bulk of the midplane. In light of the failure of the constant-α disk to produce accretion consistent with its viscosity we drop the assumption of constant-α and present an alternate model in which α varies radially according to the level magnetic turbulence or gravitoturbulence. We find that a vertical field may drive accretion across the entire disk, whereas MRI can drive accretion out to ∼ 200 R J , beyond which Toomre's Q = 1 and gravitoturbulence dominates. The disks are relatively hot (T 800 K), and consequently massive (M disk ∼ 0.5 M J ).We model a circumplanetary disk as an axisymmetric, cylindrical, radiative, thin disk surrounding a protoplanet of mass M , in orbit around a star of mass M * , at an orbital distance d. The disk extends out to a radius r = RH /3 around the planet, where

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Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown1 to be highly efficient for discovery of genetic associations2. Despite the advanced stage of illness at presentation, we have shown that host genetics in patients who are critically ill with COVID-19 can identify immunomodulatory therapies with strong beneficial effects in this group3. Here we analyse 24,202 cases of COVID-19 with critical illness comprising a combination of microarray genotype and whole-genome sequencing data from cases of critical illness in the international GenOMICC (11,440 cases) study, combined with other studies recruiting hospitalized patients with a strong focus on severe and critical disease: ISARIC4C (676 cases) and the SCOURGE consortium (5,934 cases). To put these results in the context of existing work, we conduct a meta-analysis of the new GenOMICC genome-wide association study (GWAS) results with previously published data. We find 49 genome-wide significant associations, of which 16 have not been reported previously. To investigate the therapeutic implications of these findings, we infer the structural consequences of protein-coding variants, and combine our GWAS results with gene expression data using a monocyte transcriptome-wide association study (TWAS) model, as well as gene and protein expression using Mendelian randomization. We identify potentially druggable targets in multiple systems, including inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Giant protoplanets evacuate a gap in their host protoplanetary disc, which gas must cross before it can be accreted. A magnetic field is likely carried into the gap, potentially influencing the flow. Gap crossing has been simulated with varying degrees of attention to field evolution (pure hydrodynamical, ideal, and resistive MHD), but as yet there has been no detailed assessment of the role of the field accounting for all three key non-ideal MHD effects: Ohmic resistivity, ambipolar diffusion, and Hall drift.We present a detailed investigation of gap magnetic field structure as determined by non-ideal effects. We assess susceptibility to turbulence induced by the magnetorotational instability, and angular momentum loss from large-scale fields.As full non-ideal simulations are computationally expensive, we take an a posteriori approach, estimating MHD quantities from the pure hydrodynamical gap crossing simulation by Tanigawa et al. (2012). We calculate the ionisation fraction and estimate field strength and geometry to determine the strength of non-ideal effects.We find that the protoplanetary disc field would be easily drawn into the gap and circumplanetary disc. Hall drift dominates, so that much of the gap is conditionally MRI unstable depending on the alignment of the field and disc rotation axes. Field alignment also influences the strong toroidal field component permeating the gap. Large-scale magnetic forces are small in the circumplanetary disc, indicating they cannot drive accretion there. However, turbulence will be key during satellite growth as it affects critical disc features, such as the location of the ice line.

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