We aim to investigate how antischemin preparation affects the platelet parameters in a rabbit model with alloxan induced diabetes. Methods: Rabbits were divided into 4 groups; group 1 or control group, group 2 or no antischemin group without medication, group 3 or experimental group and group 4 or comparing group. Specific parameters such as PLT, PWD, MPV, P-LCR and PCT concentration were measured on day 3, 7, 14, 21 and 28. Results: Treatment of the no antischemin group with 6% alloxan monohydrate only resulted in a significant increase of platelet level and reached the highest value at 28 th days (336.5 ± 21.2). When animals pre-treated simultaneously with antischemin for 5 days, the level of platelets did not increase significantly, compared to that in the non-treated group. After treatment of this group with 6% alloxan monohydrate, at the end of the trial (28 day), the platelet level was 274.7 ± 6.2 g/L, and in the clopidogrel pre-treated group, it was 274 ± 13.9 g/L. In the non-treated group, during the first 21 days, alloxan monohydrate caused a slight increase in PDW levels. Conclusions: Numerous studies revealed that botanical extracts which have been widely used as medicinal agents show potent anti-diabetic activity. Due to the serious side effects or resistance on synthetic drugs that are used in diabetes, the approach of using herbal remedies could be a successful alternative to the currently available diabetic treatments.

Objectives: We have aimed to determine the anti-hypoxic action of antischemin, an active anti-inflammatory drug that protects brain cells from damage and death during cerebral hemorrhage and hypoxia. Methods: We have studied antischemin made from Astragalus membraneceus roots, Scutellaria baicalensis Georgi roots, and Gingko Biloba leaves denizen in Mongolia and compared its protective effect against hypoxia compared to each of its constituents alone 6 groups of 8 mice. Normobaric hypoxia resistance as well as tissue hypoxia resistance was determined. Results: For antischemin preparation 100 mg/kg, the tolerance of normobaric hypoxia was 42 minutes or 47.2% higher in the treatment group (p < 0.001), and the latent period of hypoxia was increased by 22.7% (p < 0.05). The period of hypoxia increased 32% (p < 0.001). Conclusions: Antischemin has been shown to make tissue more resistant to hypoxia and and have more anti-hypoxic activity than its constituents alone.

Objectives: The objective, in this study is to create a pathological model of coronary heart disease in pneumonia, based on the new theory of membrane-redox potentials three-state line system-dependent -full 9 stepped cycle of proton conductance inside the human and animal body, to study the activity of respiratory dehydrogenase enzymes at the ischemic site, and the proton entry state formed by bicarbonate in the 8th stage of full chain for Traditional Medicine. Methods: The experimental model used in this study was a pathological model of myocardial ischemia as developed by Kogan and Ambaga in healthy white Wistar rats approximately weighing 200-250 ± 20g. Results: On days 3-21 of the experiment, we have observed that the proton entry formed bicarbonate decreased by 9.8-13.9% both within the red blood cell membrane surface and outside the red blood cell membrane during whole red blood cell lysis. Moreover, the level of proton depletion was high, but the unstained or cell respiration released area increased by 10.25-20.34% (p < 0.05). Conclusions: In the 8th stage ofthe full 9 stepped cycle closed chain of protons, the proton entry formed bicarbonate decreased in the red blood cell membrane surface, and ischemic standing nodule electron-proton leak and dehydrogenase enzyme activity was decreased significantly.

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