No abstract

Recently, a trend has developed towards employing certain herbal medicines to manage hepatotoxicity. The present study is that of an assessment of the efficacy of a herbal preparation of Salivin (HPS), a combination of the herbs of Saussurea amara (L.)DC., Salsola collina Pall., Achillea asiatica Serg. and rhizomes of Glycyrrhiza uralensis Fisch, in rabbit models, against CCl4-induced hepatic damage. In so doing, an extract of HPS (200 mg/kg body weight/day), along with reference control tablets of Carsil (Silymarin 35 mg) (250 mg/kg body weight/day) (which is known for its hepatoprotective effects) were administered, along with the standard diet. The experimental group of rabbits received HPS orally for 28 days, which resulted in a decrease in blood enzymes (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase), compared to the control. Evidenced by biochemical and histopathological studies, it is concluded that the polyherbal formulation HPS showed hepatoprotective activity against induced CCl4 hepatotoxicity in rabbits.

We aim to investigate how antischemin preparation affects the platelet parameters in a rabbit model with alloxan induced diabetes. Methods: Rabbits were divided into 4 groups; group 1 or control group, group 2 or no antischemin group without medication, group 3 or experimental group and group 4 or comparing group. Specific parameters such as PLT, PWD, MPV, P-LCR and PCT concentration were measured on day 3, 7, 14, 21 and 28. Results: Treatment of the no antischemin group with 6% alloxan monohydrate only resulted in a significant increase of platelet level and reached the highest value at 28 th days (336.5 ± 21.2). When animals pre-treated simultaneously with antischemin for 5 days, the level of platelets did not increase significantly, compared to that in the non-treated group. After treatment of this group with 6% alloxan monohydrate, at the end of the trial (28 day), the platelet level was 274.7 ± 6.2 g/L, and in the clopidogrel pre-treated group, it was 274 ± 13.9 g/L. In the non-treated group, during the first 21 days, alloxan monohydrate caused a slight increase in PDW levels. Conclusions: Numerous studies revealed that botanical extracts which have been widely used as medicinal agents show potent anti-diabetic activity. Due to the serious side effects or resistance on synthetic drugs that are used in diabetes, the approach of using herbal remedies could be a successful alternative to the currently available diabetic treatments.

Objectives: The objective, in this study is to create a pathological model of coronary heart disease in pneumonia, based on the new theory of membrane-redox potentials three-state line system-dependent -full 9 stepped cycle of proton conductance inside the human and animal body, to study the activity of respiratory dehydrogenase enzymes at the ischemic site, and the proton entry state formed by bicarbonate in the 8th stage of full chain for Traditional Medicine. Methods: The experimental model used in this study was a pathological model of myocardial ischemia as developed by Kogan and Ambaga in healthy white Wistar rats approximately weighing 200-250 ± 20g. Results: On days 3-21 of the experiment, we have observed that the proton entry formed bicarbonate decreased by 9.8-13.9% both within the red blood cell membrane surface and outside the red blood cell membrane during whole red blood cell lysis. Moreover, the level of proton depletion was high, but the unstained or cell respiration released area increased by 10.25-20.34% (p < 0.05). Conclusions: In the 8th stage ofthe full 9 stepped cycle closed chain of protons, the proton entry formed bicarbonate decreased in the red blood cell membrane surface, and ischemic standing nodule electron-proton leak and dehydrogenase enzyme activity was decreased significantly.