The hepatoprotective activity of the herbal preparation Salivin against carbon tetrachloride (Ccl4) induced hepatotoxicity in rabbits

Khurelbat, Daariimaa; Purevkhuu, Mandakhnaran; Luvsansharav, Batgerel; Bandi, S. C.; Tseveen, Davaasuren; Sanjjav, Tsetsegmaa; Dorjbal, Enkhjargal; Miegombo, Ambaga

doi:10.1515/cipms-2015-0030

Cited by 4 publications

(4 citation statements)

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“…The herb S. collina contains various amino acids, flavonoids, glycosides, steroids, glycoalkaloids and vitamins [ 58 , 59 ]. A previous investigation of the aerial part showed the presence of alkaloids that were isolated and identified as pericampylinone-A ( 120 ), salsoline A ( 114 ), N-trans -feruloyl-3- O -methyldopamine ( 102 ), salsoline B ( 115 ), moupinamide ( 96 ), 2′-hydroxymoupinamide ( 97 ), 2′-hydroxy-3″-methylmoupinamide ( 98 ), uracil ( 117 ), uridine ( 118 ), N -acetyltryptophan ( 121 ).…”

Section: Chemistry Of Salsolamentioning

confidence: 99%

Genus Salsola: Chemistry, Biological Activities and Future Prospective—A Review

Murshid

Atoum

Abou-Hussein

et al. 2022

Plants

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The genus Salsola L. (Russian thistle, Saltwort) includes halophyte plants and is considered one of the largest genera in the family Amaranthaceae. The genus involves annual semi-dwarf to dwarf shrubs and woody tree. The genus Salsola is frequently overlooked, and few people are aware of its significance. The majority of studies focus on pollen morphology and species identification. Salsola has had little research on its phytochemical makeup or biological effects. Therefore, we present this review to cover all aspects of genus Salsola, including taxonomy, distribution, differences in the chemical constituents and representative examples of isolated compounds produced by various species of genus Salsola and in relation to their several reported biological activities for use in folk medicine worldwide.

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Section: Chemistry Of Salsolamentioning

confidence: 99%

Genus Salsola: Chemistry, Biological Activities and Future Prospective—A Review

Murshid

Atoum

Abou-Hussein

et al. 2022

Plants

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“…The most significant pathological characteristics of CCl 4 -induced hepatotoxicity are fatty liver, cirrhosis, and necrosis [7].…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective Effect of Chenopodium Quinoa Seed Against Ccl4-Induced Liver Toxicity in Swiss Albino Male Mice

Saxena

Shahani

Bhatnagar

2017

Asian J Pharm Clin Res

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Objective:To study the effect of Quinoa seed on carbon tetrachloride (CCL 4 )-induced liver toxicity in Swiss albino male mice. Methods:Swiss albino male mice were divided into three groups: Group 1 served as control group; Group 2 served as hepatotoxic group (CCl 4 treated); and Group 3 served as combination of Quinoa seed powder (20 mg/kg) + CCl 4 -treated group. The effect of these groups on liver tissue was studied after three different periods of 4, 8, and 12 weeks. Liver marker enzyme level of serum glutamic-oxaloacetic transaminase, serum glutamic-pyruvic transaminase, serum alkaline phosphatase and liver antioxidant enzyme level of lipid peroxidation, superoxide dismutase, and reduced glutathione were measured. Further, histopathological analysis of liver was also conducted. Results:The results showed that the treatment with Quinoa seed powder significantly reduced CCl 4 -induced elevated serum level of hepatic enzymes and restored the level of liver antioxidant enzymes toward the normal levels, which was also confirmed by histopathological studies. Conclusion:Results of the present study concluded that the Quinoa seed (Chenopodium quinoa) showed hepatoprotective effect against CCl 4 -induced liver damage in Swiss albino male mice.

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“…The chemical agent used for inducing hepatic injury was "CCl 4 " (Sigma Chemicals, USA). It was given subcutaneously to 48 rabbits every alternate day for 3 weeks with a dose of 0.2 ml/kg (26).…”

Section: Induction Of Hepatic Injurymentioning

confidence: 99%

Comparative pharmacokinetic study of theaflavin in healthy and experimentally induced liver damage rabbits

Sarhan¹

2019

IJVS

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This current work aimed to study the pharmacokinetics of theaflavin in healthy and hepatotoxic rabbits for comparison. Aspartate aminotransferase (AST), alkaline phosphatase (ALP) and alanine aminotransferase (ALT) were significantly raised (P<0.05) after administration of 0.2 mg/kg body weight (BW) Carbone tetrachloride (CCL4) subcutaneously. Pharmacokinetic parameters calculated following administration of theaflavin intravenously and orally at 30 mg/kg and 500 mg/kg respectively to both healthy animals and those with damaged liver. Theaflavin concentration in blood measured by HLPC at various time intervals. Pharmacokinetic results showed that theaflavin concentration when given orally reached its maximum concentration after 5 hours in healthy rabbits. While in hepatotoxic group, theaflavin concentration achieved the highest level in blood after three hours. Theaflavin bioavailability in hepatotoxic animals was significantly high and almost double its bioavailability in healthy animals. Results revealed that the area under curve (AUC) value in rabbits with damaged liver was significantly greater than in healthy group (P<0.05). t ½ of theaflavin after intravenous administration was 6.3±0.82 hour in damaged liver group which is significantly higher than that in healthy group (P<0.05). Theaflavin mean concentration in hepatotoxic group required more than 3 hours to decline to 352±19.4 ng/ml when compared to its concentration in healthy group which is required only 45 minutes to decrease to 310± 9.5 ng/ml. In conclusion liver has critical impact on the pharmacokinetics of theaflavin especially bioavailability and biotransformation and this research recorded reasonably large differences between healthy and liver damaged groups regarding theaflavin pharmacokinetic parameters which may result in negative influences on its biological efficacy when used in the treatment of various diseases.

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The hepatoprotective activity of the herbal preparation Salivin against carbon tetrachloride (Ccl4) induced hepatotoxicity in rabbits

Cited by 4 publications

References 10 publications

Genus Salsola: Chemistry, Biological Activities and Future Prospective—A Review

Genus Salsola: Chemistry, Biological Activities and Future Prospective—A Review

Hepatoprotective Effect of Chenopodium Quinoa Seed Against Ccl4-Induced Liver Toxicity in Swiss Albino Male Mice

Comparative pharmacokinetic study of theaflavin in healthy and experimentally induced liver damage rabbits

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