Background:Controlling superficial bleeding, despite all the progress in surgical science, is still a challenge in some settings.Objectives:This study assesses the hemostatic effects of ferric chloride and compares it with the standard method (suturing technique) to control superficial bleeding.Materials and Methods:In this animal model study, 60 male Wistar rats were used. An incision, 2 cm long and 0.5 cm deep was made on rat skin and the hemostasis time was recorded using ferric chloride at different concentrations (5%, 10%, 15%, 25%, and 50%) and then using a control (i.e. control of bleeding by suturing). The skin tissue was examined for pathological changes. Finally, the obtained data were entered into SPSS (ver. 16) and analyzed using Kruskal-Wallis test, Mann-Whitney, Kolmogorov-Smirnov, and Wilcoxon signed ranks test.Results:The hemostasis time for the ferric chloride concentration group was significantly less than for the control group (P < 0.001).Conclusions:Ferric chloride may be an effective hemostatic agent to control superficial bleeding in rats.