Background: Clarithromycin and amoxycillin are antibiotics commonly used in association for Helicobacter pylori eradication. Because this treatment, which lasts 1–2 weeks, is frequently associated with gastrointestinal symptoms, we investigated the effects of these antibiotics on gastrointestinal motility. Patients and methods: Gastroduodenal motility was recorded in 14 patients with functional dyspepsia and H. pylori gastritis by means of a low‐compliance manometric system with four recording ports in the stomach and four in the duodenum. Two tablets of clarithromycin 250 mg (seven patients, clarithromycin group) or one of amoxycillin 1 g (seven patients, amoxycillin group), ground and dissolved in 20 mL of water, were given randomly and in double‐blind manner 30 min after the end of the first activity front (AF) of the migrating motor complex (MMC) or, in the absence of AFs, after at least 200 min of recording. Recording continued until an AF was observed during the subsequent 200 min. Results: Clarithromycin administration was followed by a typical gastroduodenal AF in a significantly higher number of patients than for amoxycillin administration. In addition, the time lag between clarithromycin administration and the appearance of AFs was 48 min ± 8.5 (mean ± s.d.), significantly shorter than after amoxycillin (121 min ± 29). The clarithromycin‐related duodenal AFs showed a duration of 6.6 min ± 1.5, significantly longer than that of the spontaneous AFs (3.6 min ± 1.2, P < 0.01), while the amoxycillin‐related AFs were not significantly different from the spontaneous ones. Conclusion: Clarithromycin stimulated cyclic gastroduodenal motility, while amoxycillin was ineffective. It is likely that symptoms during the eradication treatment are due to this effect of clarithromycin.

Leonardo has been involved in the realization of several infrared payloads for Earth Observation since 1990. Among the currently in orbit operative instruments we find the two SLSTRs and PRISMA. The SLSTRs are high accuracy radiometers of the Copernicus mission related to ESA Sentinel-3 space component to provide Sea Surface Temperature (SST) data continuity respect to previous (A)ATSRs for climatology in the next 20-years. The PRISMA Program is the first ASI (Agenzia Spaziale Italiana) optical hyperspectral mission for Earth observation. It is based on a high spectral resolution spectrometer operating in the VIS-SWIR channels optically integrated with a panchromatic camera.

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