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Abstract. When designing password-authenticated key exchange protocols (as opposed to key exchange protocols authenticated using cryptographically secure keys), one must not allow any information to be leaked that would allow verification of the password (a weak shared key), since an attacker who obtains this information may be able to run an off-line dictionary attack to determine the correct password. We present a new protocol called PAK which is the first Diffie-Hellman-based passwordauthenticated key exchange protocol to provide a formal proof of security (in the random oracle model) against both passive and active adversaries. In addition to the PAK protocol that provides mutual explicit authentication, we also show a more efficient protocol called PPK that is provably secure in the implicit -authentication model. We then extend PAK to a protocol called PAK-X, in which one side (the client) stores a plaintext version of the password, while the other side (the server) only stores a verifier for the password. We formally prove security of PAK-X, even when the server is compromised. Our formal model for passwordauthenticated key exchange is new, and may be of independent interest.

Purpose In this work, we tested the hypothesis that microneedles provide a minimally invasive method to inject particles into the suprachoroidal space for drug delivery to the back of the eye. Methods A single, hollow microneedle was inserted into the sclera, and infused nanoparticle and microparticle suspensions into the suprachoroidal space. Experiments were performed on whole rabbit, pig, and human eyes ex vivo. Particle delivery was imaged using brightfield and fluorescence microscopy as well as microcomputed tomography. Results Microneedles were shown to deliver sulforhodamine B as well as nanoparticle and microparticle suspensions into the suprachoroidal space of rabbit, pig, and human eyes. Volumes up to 35 μL were administered consistently. Optimization of the delivery device parameters showed that microneedle length, pressure, and particle size played an important role in determining successful delivery into the suprachoroidal space. Needle lengths of 800–1,000 μm and applied pressures of 250–300 kPa provided most reliable delivery. Conclusions Microneedles were shown for the first time to deliver nanoparticle and microparticle suspensions into the suprachoroidal space of rabbit, pig and human eyes. This shows that microneedles may provide a minimally invasive method for controlled drug delivery to the back of the eye.

Injection into the suprachoroidal space using a microneedle offers a simple and minimally invasive way to target the delivery of drugs to the choroid and retina.

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